|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-15 is implicated in the pathogenesis of various autoimmune diseases such as rheumatoid arthritis, inflammatory bowel disease, psoriasis and autoimmune type 1 diabetes (T1D).
|
26853723 |
2017 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show that endogenous soluble IL-15 receptor α (IL-15Rα) derived from epidermal stroma, notably keratinocytes, protects against dendritic cell/IL-15-mediated, T cell-driven skin inflammation in vivo, and is relevant to human psoriasis.
|
24019554 |
2013 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variants of the gene IL15 encoding IL-15 have been identified that associate with psoriasis in a Chinese population.
|
18830267 |
2009 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
No association between polymorphisms in the interleukin-15 gene and early-onset psoriasis in a UK cohort suggests heterogeneity for this susceptibility locus identified in Chinese psoriasis patients.
|
18580966 |
2008 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Role of the interleukin 15 96516A>T and IL15 96330C>A gene polymorphisms in Caucasian patients with chronic plaque psoriasis.
|
18424079 |
2008 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
(2007, this issue) report a significant genetic association between IL-15 and psoriasis, which may involve increased stability of IL-15 mRNA.
|
17934500 |
2007 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Therefore, we provided early evidence for the important role of IL-15 genetic variants in the pathogenesis of psoriasis, probably by increasing interleukin production and inflammation in the lesions of psoriasis.
|
17554368 |
2007 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we provided early evidence for the important role of IL-15 genetic variants in the pathogenesis of psoriasis, probably by increasing interleukin production and inflammation in the lesions of psoriasis.
|
17554368 |
2007 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The membrane-bound IL-15 expression was also significantly lower in the control monocytes of AD patients compared with that in normals and psoriasis patients.
|
11751999 |
2002 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Despite similar expression of IL-15 mRNA, we found differences in IL-15 protein expression between normal human skin, atopic dermatitis and psoriasis on the one hand, and parapsoriasis and CTCL on the other.
|
11359391 |
2001 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, antagonizing the inhibitory effects of IL-15 on KC apoptosis deserves exploration as a novel therapeutic strategy in psoriasis management.
|
10925312 |
2000 |