|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Initial dosing studies identified sub-therapeutic levels of IL-13 and IL-17A blocking mAbs that have a limited effect on asthma parameters and do not impair responses to microbial products or infection.
|
30353972 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
IL-17A is associated with asthma and chronic obstructive pulmonary disease pathogenesis; however, IL-17A regulation of IFN-λ expression remains unclear.
|
30224514 |
2018 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
To investigate the role of IL-17-derived neutrophils in airway remodelling in chronic bronchial asthma.
|
30171733 |
2018 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Recent studies clearly show that not only Th2 cytokines but also other T cell-related cytokines such as IL-17A and IL-22 as well as epithelial cell cytokines such as IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) are involved in the pathogenesis of asthma.
|
28658544 |
2017 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
However, aberrant expression or overexpression of IL-17 cytokines contributes to a number of pathological outcomes, including asthma, pneumonitis, and generation or exacerbation of pulmonary fibrosis.
|
28860146 |
2018 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
It will further review the evidence demonstrating the extent to which IL-17A interacts with various immune factors, specifically TGF-β1, to contribute to ASM remodeling and altered function in T<sub>H</sub>17-driven endotypes of severe asthma.
|
30810068 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A.
|
22005301 |
2011 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In conclusion, the activation of innate immune pathways in the airways suggests that activated T cells may be driving neutrophilic inflammation and steroid-insensitive IL-17 response in severe asthma.
|
28933920 |
2018 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
However, there were no correlations between ILC3 frequencies or the expressions of RORC, IL-17A, and IL-22 and asthma severity.
|
30622974 |
2018 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Taken together, our results show that Arhgef12 is necessary for IL17A-induced airway contractility and identify a therapeutic target for severe asthma.
|
30385725 |
2018 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
CXCL-1, IL-5, IL-8, and IL-17A were positively associated with Difficult-to-Control asthma, while IL-4 and IL-13 were positively associated with Easy-to-Control asthma.
|
28686637 |
2017 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In conclusion, inactivated M. phlei may be an effective antiasthmatic treatment, regulating IL‑17‑producing γδT (IL‑17+γδT) cell‑mediated airway inflammation and airway hyperresponsiveness to relieve the symptoms of mice with asthma.
|
28035388 |
2017 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Recently, IL-17A has been shown to be expressed in higher levels in respiratory secretions from asthmatics and correlated with airway hyperresponsiveness.
|
16951370 |
2006 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The suppression of IL-23/IL-17 axis could be considered a molecular therapeutic target for fenofibrate in OVA/LPS-induced airway inflammation and bronchial asthma.
|
29288381 |
2018 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Among patients, IL17A rs2275913 AA genotype was less associated with asthma than with rhinitis (OR - 0.20; 95% CI of 0.07 to 0.56; p=0.002).
|
27561723 |
2018 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In an experimental model of fungal-associated allergic airway inflammation, we demonstrate that IL-1R1 signaling promotes type 1 (IFN-γ, CXCL9, CXCL10) and type 17 (IL-17A, IL-22) responses that were associated with neutrophilic inflammation and increased airway hyperreactivity.
|
31550242 |
2019 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Bronchoalveolar lavage fluid from patients with severe asthma and high neutrophil counts had detectable NETs and cytoplasts that were positively correlated with IL-17 levels.
|
30076281 |
2018 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrated that asthma patients presented with higher frequencies of GA genotype in rs2275913 and TT genotype in rs8193036 of IL-17 than healthy controls (both P<0.001).
|
26954344 |
2016 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Although originally defined as a type 2 (T2) immune-mediated condition, non-T2 cytokines, such as IFN-γ and IL-17A, have been implicated in asthma pathogenesis, particularly in patients with severe disease.
|
31445933 |
2020 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
To assess vascular remodelling in severe asthma and whether IL-17A directly or indirectly may cause endothelial cell activation and angiogenesis.
|
29337379 |
2018 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The findings showed that the extract of <i>Z. multiflora</i> decreased pro-inflammatory cytokines in asthma (IL-4 and IL-17 and TGF-β) but increased anti-inflammatory cytokines (IFN-γ) gene expression and the number of Treg (FOXP3) in splenocytes of asthmatic mice which may indicate the specific therapeutic effect of the plant extract in allergy, autoimmunity, and infectious diseases via potentiating Th<sub>1</sub> and suppressing Th2 and Th<sub>17</sub> cells.
|
28824424 |
2017 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
This study estimates the effects of anti-IL-17 therapy in the pulmonary parenchyma in a murine asthma model exacerbated by LPS.
|
29379497 |
2017 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Genotyping showed that AG heterozygotes of rs17880588 in IL17A were significantly more common in the control group than among the asthma patients (P < .05); no significant associations were observed for any of the other SNPs examined.
|
22312940 |
2011 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The effects of neutralizing anti-murine interleukin-17A monoclonal antibody on ozone-induced inflammation and glucocorticoids insensitivity in a murine model of asthma.
|
30917335 |
2019 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We investigated the possible association among asthma and IL-17A -197G/A (rs2275913), IL-17F 7488A/G (rs763780) and IL-17F 7383A/G (rs2397084).
|
24393079 |
2014 |