|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Although originally defined as a type 2 (T2) immune-mediated condition, non-T2 cytokines, such as IFN-γ and IL-17A, have been implicated in asthma pathogenesis, particularly in patients with severe disease.
|
31445933 |
2020 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Serum levels of IL-5, IL-6, IL-8, IL-13 and IL-17A (ELISA) were measured in 30 healthy controls (HC) and 80 adult BA patients.BA patients were split into 4 groups.
|
31260861 |
2020 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Initial dosing studies identified sub-therapeutic levels of IL-13 and IL-17A blocking mAbs that have a limited effect on asthma parameters and do not impair responses to microbial products or infection.
|
30353972 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
It will further review the evidence demonstrating the extent to which IL-17A interacts with various immune factors, specifically TGF-β1, to contribute to ASM remodeling and altered function in T<sub>H</sub>17-driven endotypes of severe asthma.
|
30810068 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In an experimental model of fungal-associated allergic airway inflammation, we demonstrate that IL-1R1 signaling promotes type 1 (IFN-γ, CXCL9, CXCL10) and type 17 (IL-17A, IL-22) responses that were associated with neutrophilic inflammation and increased airway hyperreactivity.
|
31550242 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The effects of neutralizing anti-murine interleukin-17A monoclonal antibody on ozone-induced inflammation and glucocorticoids insensitivity in a murine model of asthma.
|
30917335 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
This study aimed to investigate the pathogenesis of geriatric asthma through immunoglobulin E (IgE), interleukin-17A (IL-17A), IL-17F, and glucocorticoid receptor-β (GR-β) expression.
|
30304965 |
2019 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
IL-17A levels were positively correlated with FeNO values in severe asthmatics with eosinophils>400 cells/μl.
|
31047104 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
However, Th17 response cytokines IL-17 and IL-1β were only elevated in RV-C-infected children with pre-existing asthma.
|
31703379 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
A subset of asthma patients also exhibits elevated IL-17, which is associated with greater disease severity, neutrophilic inflammation, and steroid resistance.
|
30616547 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the relationships between adherence to MD and serum levels of certain cytokines namely, interleukin (IL)-4, and IL-17 known to have a pathogenetic role in the airway changes associated with asthma.
|
29980401 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
IL-17A is a critical proinflammatory cytokine for the pathogenesis of asthma including neutrophilic pulmonary inflammation and airway hyperresponsiveness.
|
30683702 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The T<sub>H</sub>17 lymphocytes producing IL-17A and IL17-F cytokines, may have a role on asthma inflammation.
|
31168303 |
2019 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Excluding smokers revealed increased IL-17A<sup>+</sup> and IL-22<sup>+</sup> cells in highly neutrophilic patients.We provide new evidence linking the presence of high bronchial neutrophilia in asthma to an adaptive immune response associated with allergy (IgE) and IL-17/22 cytokine expression.
|
31439682 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In terms of the adaptive T-lymphocyte immunity, CD4+ Th2 and IL-17-producing cells are critical in the inflammatory responses in asthma.
|
30691715 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
However, further elucidation of the complex interactions unfurled by IL-17 is essential in the empirical development of effective therapeutic options for refractory asthmatics.
|
31498708 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
This study aims to investigate the role of IL-17A and IL-10 in predicting asthma control in case of Vit D supplementation.
|
31570180 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
IL-17A synergises with tumour necrosis factor (TNF)-α in the production of the neutrophil chemokine CXCL-8 by primary bronchial epithelial cells (PBECs).We hypothesised that local neutrophilic inflammation in asthma correlates with IL-17A and TNF-α-induced CXCL-8 production by PBECs from asthma patients.PBECs from most asthma patients displayed an exaggerated CXCL-8 production in response to TNF-α and IL-17A, but not to TNF-α alone, and which was also insensitive to corticosteroids.
|
31109984 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Studies of IL-17 inhibitors for other indications including psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, and asthma yielded similar results.
|
30900514 |
2019 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
However, glucocorticoids also enhance the synthesis of IL-17A by PBMCs, which, in excess, is associated with increased asthma severity and glucocorticoid-refractory disease.
|
30598515 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
This study aimed to investigate the impact of cigarette smoking and IL-17A activation on the clinical outcomes of asthmatic patients with chronic rhinosinusitis.
|
30609423 |
2019 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We further found that seminal fluid from middle-aged human volunteers had beneficial effects in asthmatic female mice; these effects were associated with transcriptional repression of osteopontin and IL-17A, which are poor prognostic factors for asthma.
|
30677748 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
IL-17-high asthma with features of a psoriasis immunophenotype.
|
30998987 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
IL-17 plays a pathogenic role in asthma.
|
29625134 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
IL-17A is associated with asthma and chronic obstructive pulmonary disease pathogenesis; however, IL-17A regulation of IFN-λ expression remains unclear.
|
30224514 |
2018 |