Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Treatment of C3H.IL-10(-/-) mice with fenofibrate delayed the onset of colitis, decreased the colonic histopathology score, and decreased colonic expression of genes encoding the inflammatory cytokines interferon-gamma and interleukin (IL)-17.
|
17631136 |
2007 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Antibody-mediated blockade of interleukin-17 (IL-17) as well as the receptor for IL-23, a key cytokine amplifying T(H)17 responses, inhibits ETBF-induced colitis, colonic hyperplasia and tumor formation.
|
19701202 |
2009 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Colitis was associated with a 6-fold expansion of CD4+ IL-17-expressing T cells.
|
19714651 |
2009 |
Colitis
|
0.600 |
Biomarker
|
disease |
RGD |
Bovine glycomacropeptide has intestinal antiinflammatory effects in rats with dextran sulfate-induced colitis.
|
20881082 |
2010 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the role of CD30L in the development of colitis experimentally induced by dextran sulfate sodium (DSS), in which IL-17A is involved in the pathogenesis.
|
21068411 |
2010 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tissue with active colitis had a prominent population of mucosal T helper (T(H)) cells that produced the inflammatory cytokine interleukin-17 (IL-17) but not IL-22, a cytokine involved in mucosal healing.
|
21123809 |
2010 |
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
IRF4 regulates IL-17A promoter activity and controls RORγt-dependent Th17 colitis in vivo.
|
21305677 |
2011 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Absolute numbers of IL-17(+) or IFN-γ(+) CD4(+) T cells per colon were less in mice receiving Daikenchuto than in mice that received control feed, as both groups received naive CD4(+) T cells to induce colitis.
|
22610884 |
2012 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
[Nature 2010;464:1371-1375] recently reported the accumulation of IL-23-responsive innate lymphoid cells in the colon, the former capable of producing IL-17 and interferon γ and mediating innate colitis in mice.
|
22796792 |
2012 |
Colitis
|
0.600 |
Biomarker
|
disease |
CTD_human |
Involvement of TACE in colon inflammation: a novel mechanism of regulation via SIRT-1 activation.
|
24548422 |
2014 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our data provide insight into the complex network of interactions between IL-17A-secreting ILCs and other components of the innate immune system in the development of colitis.
|
24927559 |
2014 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Colitis-associated Batf(-/-) tumours lacked IL-17a(+)IL-23R(+)IL-6(+)CD4(+) T cells, hence displaying characteristics reminiscent of human CRC-infiltrating CD4(+) T cells.
|
25838550 |
2016 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Altogether, the AA-mTORC1-IL-17 axis has broad therapeutic implications for IL-17-associated diseases, such as EAE, allergies, and colitis.
|
26558536 |
2016 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Transfer of CD101(-/-) T cells caused more severe colitis and was associated with an expansion of IL-17-producing T cells and an enhanced expression of IL-2Rα/β independently of FoxP3.
|
26813346 |
2016 |
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The degree of colitis was associated with general changes in the complexity of the microbiota and was corroborated by quantitative analyses of the Bacteroides and Lactobacillus High gene expression levels of IL-17 and IFN-γ in colon and caecum were detected in Gαi2(-/-) mice with moderate and severe colitis.
|
27162181 |
2016 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-γt ubiquitination.
|
27322655 |
2016 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
When transferred in vivo, Th17 cells lacking Ndfip1 were more likely to maintain their ability to make IL-17, were more potent proinflammatory cytokine producers, and were powerful inducers of colitis.
|
28051111 |
2017 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The loss of NLRX1 results in increased disease severity, populations of Th1 and Th17 cells, and inflammatory markers (IFN-γ, TNF-α, and IL-17) in mice with dextran sodium sulfate-induced colitis.
|
28159898 |
2017 |
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Mechanically, reduced NF-κВ DNA phosphorylation activity and downregulated TNF-α, IL-1β, IL-6, IL-17 expressions and myeloperoxidase (MPO) activity were associated with improvement in colitis observed in APS-treated mice.
|
28188801 |
2017 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Consistent with this, IL-17-induced inflammation is significantly reduced in <i>NDR1-</i>deficient mice, and NDR1 deficiency significantly protects mice from MOG-induced experimental autoimmune encephalomyelitis (EAE) and 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis likely by its inhibition of IL-17-mediated signaling pathway.
|
28219902 |
2017 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
IL-17 A inhibition, IL-17RA inhibition and IL-17 knockout led to induction or exacerbation of colitis in mouse models.
|
28521565 |
2018 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Secreted protein acidic and rich in cysteine functions in colitis via IL17A regulation in mucosal CD4<sup>+</sup> T cells.
|
28582593 |
2018 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We have recently reported that FGF2 cooperates with IL-17 to protect intestinal epithelium during dextran sodium sulfate (DSS)-induced colitis.
|
28765647 |
2017 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results suggested that CoQ10 may reduce the severity of colitis and suppress inflammation through the inhibition of p-STAT3 and IL-17.
|
28816577 |
2017 |
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Melatonin stifled the expression of colonic IL-17 in mice with DSS-induced colitis.
|
28929336 |
2017 |