Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Colitis was associated with a 6-fold expansion of CD4+ IL-17-expressing T cells.
|
19714651 |
2009 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Colitis-associated Batf(-/-) tumours lacked IL-17a(+)IL-23R(+)IL-6(+)CD4(+) T cells, hence displaying characteristics reminiscent of human CRC-infiltrating CD4(+) T cells.
|
25838550 |
2016 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
A model of TH17-associated ileal hyperplasia that requires both IL-17A and IFNγ to generate self-tolerance and prevent colitis.
|
29728642 |
2018 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Absolute numbers of IL-17(+) or IFN-γ(+) CD4(+) T cells per colon were less in mice receiving Daikenchuto than in mice that received control feed, as both groups received naive CD4(+) T cells to induce colitis.
|
22610884 |
2012 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Altogether, the AA-mTORC1-IL-17 axis has broad therapeutic implications for IL-17-associated diseases, such as EAE, allergies, and colitis.
|
26558536 |
2016 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Antibody-mediated blockade of interleukin-17 (IL-17) as well as the receptor for IL-23, a key cytokine amplifying T(H)17 responses, inhibits ETBF-induced colitis, colonic hyperplasia and tumor formation.
|
19701202 |
2009 |
Colitis
|
0.600 |
Biomarker
|
disease |
RGD |
Bovine glycomacropeptide has intestinal antiinflammatory effects in rats with dextran sulfate-induced colitis.
|
20881082 |
2010 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Compared with the control group, TNBS‑treated mice had significantly higher secretion of IL‑17, higher DAI scores, a lower ratio of Treg, reduced colon lengths and higher histological scores for colon inflammation.
|
29620246 |
2018 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Consistent with this, IL-17-induced inflammation is significantly reduced in <i>NDR1-</i>deficient mice, and NDR1 deficiency significantly protects mice from MOG-induced experimental autoimmune encephalomyelitis (EAE) and 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis likely by its inhibition of IL-17-mediated signaling pathway.
|
28219902 |
2017 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Contrastingly, enterotoxigenic Bacteroides fragilis (ETBF) is highly associated with inflammatory bowel disease (IBD) and colorectal cancer (CRC), rapidly inducing IL-17-dependent murine colitis and tumorigenesis.
|
30279518 |
2019 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
IL-17 A inhibition, IL-17RA inhibition and IL-17 knockout led to induction or exacerbation of colitis in mouse models.
|
28521565 |
2018 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
IL23 responsive ILC have been implicated in the pathogenesis of colitis in several innate murine models through the production of IL17, IFNγ, and GM-CSF.
|
29081776 |
2017 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Importantly, injection of anti-IL-17 intraperitoneally partially protected P2ry6<sup>-</sup><sup>/</sup><sup>-</sup> mice from DSS-induced colitis.
|
31271845 |
2019 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Importantly, intestinal NIK signaling is active in mouse models of colitis and patients with inflammatory bowel diseases; meanwhile, constitutive NIK signaling increases the susceptibility to inflammatory injury by inducing ectopic M-cell differentiation and a chronic increase of IL-17A.
|
30737385 |
2019 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In a 2,4,6-trinitrobenzenesulfonic acid-induced colitis model, mice carrying VDR deletion in gut epithelial cells [VDRflox/flox (VDRf/f);Villin-Cre or VDRΔIEC] or in colonic epithelial cells (VDRf/f;CDX2-Cre or VDRΔCEC) developed more severe clinical colitis than VDRf/f control mice, characterized by more robust T-helper (TH)1 and TH17 responses, with greater increases in mucosal interferon (IFN)-γ+, interleukin (IL)-17+, and IFN-γ+IL-17+ T cells.
|
29228157 |
2018 |
Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In addition, key cytokines associated with colitis (IL-1β, IL-6, and IL-17A) were significantly suppressed, following treatment with M2b macrophage exosomes.
|
31749791 |
2019 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In the absence of IFNγ, intestinal inflammation in CD4 T cell recipient mice was associated with enhanced IL17 responses; consequently, targeting IL17 signaling in IFNγ-deficient mice reduced T cell-mediated colitis.
|
29416538 |
2018 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we evaluated the effect of IL-17A on colitis in IL-10-deficient (Il10-/-) mice.
|
31755523 |
2020 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the role of CD30L in the development of colitis experimentally induced by dextran sulfate sodium (DSS), in which IL-17A is involved in the pathogenesis.
|
21068411 |
2010 |
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Increased levels of IL-17 and RORγt were also observed in this animal model of colitis with Hhcy.
|
29974377 |
2018 |
Colitis
|
0.600 |
Biomarker
|
disease |
CTD_human |
Involvement of TACE in colon inflammation: a novel mechanism of regulation via SIRT-1 activation.
|
24548422 |
2014 |
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
IRF4 regulates IL-17A promoter activity and controls RORγt-dependent Th17 colitis in vivo.
|
21305677 |
2011 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-γt ubiquitination.
|
27322655 |
2016 |
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Mechanically, reduced NF-κВ DNA phosphorylation activity and downregulated TNF-α, IL-1β, IL-6, IL-17 expressions and myeloperoxidase (MPO) activity were associated with improvement in colitis observed in APS-treated mice.
|
28188801 |
2017 |
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Melatonin stifled the expression of colonic IL-17 in mice with DSS-induced colitis.
|
28929336 |
2017 |