|
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Chronic airway obstruction is mainly induced by IL17 as shown across models.
|
30502290 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
After Bonferroni correction, polymorphisms rs2275913 and rs763780 in the IL17A gene, rs10759932 and rs2737190 in the TLR4 gene, and rs1718119 in the P2RX7 gene were significantly associated with altered risk for COPD.
|
29704988 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
We generated a gene expression signature of IL-17A response in bronchial airway epithelial brushings from smokers with and without COPD (n = 238), and validated it using data from 2 randomized trials of IL-17 blockade in psoriasis.
|
30383540 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
The secretion of IL-17 was significantly higher from COPD-PH CD4<sup>+</sup> T cells than from control CD4<sup>+</sup> T cells, whereas the secretion of interferon-γ and IL-4 was not significantly different.
|
31141166 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, remarkable increased level of IL17 and IL-6 and decreased level of IL-10 and TGF-ß were observed in the bronchiectasis combined COPD than in pure COPD (All P<0.05).
|
31503552 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
For inflammatory cytokines, lncRNA ANRIL expression was negatively correlated with TNF-α (P < 0.001), IL-1β (P = 0.015), IL-8 (P = 0.008), IL-17A (P = 0.002), and LTB-4 (P = 0.004) in AECOPD patients, while it was negatively correlated with TNF-α (P = 0.049), IL-1β (P = 0.005), IL-17A (P = 0.030), and LTB-4 (P = 0.011) in stable COPD patients.
|
30230590 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Interleukin-17A (IL-17A) is a pro-inflammatory cytokine mainly derived from T helper 17 cells and is known to be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD).
|
29463070 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Collectively, the results of the present study suggest that IL-17A and GDF15-induced EMT serves an important role in the pathology of COPD.
|
29977354 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
A significant difference was found in the expression levels of IL-17A in smokers with COPD patient when compared to smokers without COPD and the control subjects.
|
30250995 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
CD80 and FoxP3 levels were lower, and CCR6 and IL-17A levels were higher obviously in COPD compared to non-COPD patients (p < 0.05).
|
30372815 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
TSLP and IL-17A were measured in induced sputum supernatants (ISs) from healthy controls (HC), healthy smokers (HS), and COPD patients by enzyme-linked immunosorbent assay.
|
30291224 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Studies show that IL-17 plays an important role in some inflammatory diseases of the airways, including asthma and chronic obstructive pulmonary disease.
|
30077332 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
IL-17A is associated with asthma and chronic obstructive pulmonary disease pathogenesis; however, IL-17A regulation of IFN-λ expression remains unclear.
|
30224514 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The serum levels of IL-17, IL-10, and IL-35 correlated with the clinical factors of COPD, indicating that they can serve as indicators to estimate the progression of COPD.
|
30154651 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
The expression, localization and functional relevance of IL-17 receptor (R)A and IL-17RC was explored in COPD by immunodetection, and functional assays.IL-17RA and IL-17RC was increased in very severe COPD, and expressed by mast cells.
|
28298222 |
2017 |
|
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here a role for IL-17A in airway fibrosis was demonstrated using mice deficient in the IL-17 receptor A (il17ra) Il17ra-deficient mice were protected from both airway inflammation and fibrosis in two different models of airway fibrosis that employ COPD-relevant stimuli.
|
27913421 |
2017 |
|
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
In this review, we describe current knowledge on the involvement of IL-17 and IL-22 in COPD pathophysiology at steady state and during exacerbations, and discuss implications for COPD management and future therapeutic approaches.
|
29025886 |
2017 |
|
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
This study was undertaken to evaluate the serum IL-1β and IL-17 levels and associations between these two key mediators with clinical parameters in COPD patients.
|
28490868 |
2017 |
|
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
IL-17 gene expression level considerably was higher in SM patients (9.98±0.65, p<0.001), and COPD (4.75±0.71, p<0.001), compare to HC group.
|
29149779 |
2017 |
|
Chronic Obstructive Airway Disease
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In Tatar population, significant associations of JAK1 (rs310216) (P = 0.0002, OR 1.70 in additive model), JAK3 (rs3212780) (P = 0.001, OR 1.61 in dominant model), and IL17A (rs1974226) (P = 0.0037, OR 2.31 in recessive model) with COPD were revealed.
|
27003425 |
2016 |
|
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In contrast with non-smokers, blood NK and NKT cells from COPD patients failed to increase IL-17 and IL-22 levels in response to S. pneumoniae, in association with a defect in IL-1β and IL-23 secretion.
|
26870795 |
2015 |
|
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Increasing evidence supports elevated IL-17 expression in the lung of COPD subjects.
|
25427574 |
2014 |
|
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Chronic diseases such as asthma and chronic obstructive pulmonary disease have been associated with IL-17 and IL-22 responses directed against innocuous antigens.
|
24942687 |
2014 |
|
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Increased CD4(+)IL-17(+) cell number in lung tissue is involved in chronic inflammation of the lungs and parallels lung injury aggravation in COPD patients and in smokers without airway limitations.
|
23127823 |
2013 |
|
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
After adjusting for the total number of cells in the submucosa, we still found that more cells were positive for both IL-17A (P < 0.0001) and IL-17F (P < 0.0001) in COPD patients compared to controls.
|
21477350 |
2011 |