IL18, interleukin 18, 3606

N. diseases: 750; N. variants: 18
Disease: Glomerulonephritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis 		0.320 GeneticVariation disease BEFREE These results show that the -607CC genotype of the IL-18 gene and the 405GG genotype of the VEGF gene are associated with susceptibility to and the development of primary GN. 20545903 2010
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis 		0.320 Therapeutic disease CTD_human To investigate the role of IL-18 in BSA glomerulonephritis, we used IL-18R-deficient C57BL/6 mice. 18462998 2008
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis 		0.320 Biomarker disease BEFREE Vaccinated mice produced autoantibodies to murine IL-18 and exhibited a significant reduction in spontaneous lymphoproliferation and IFN-gamma production as well as less glomerulonephritis and renal damage. 14615579 2003