Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Results showed an upregulation of proinflammatory cytokines, including interleukin-1β and interleukin-18, and macrophage infiltration in bursa in response to vvIBDV infection.
|
31632367 |
2019 |
Inflammatory Bowel Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Firstly, meta‑analysis was used to explore whether the levels of IL‑18 were different in patients with colon cancer or inflammatory bowel disease.
|
31017261 |
2019 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Moloc strengthened evidence of a causal association for these results, as well as providing evidence of a monocyte and neutrophil-driven role for IL-18 in IBD pathogenesis.
|
31276585 |
2019 |
Inflammatory Bowel Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Given that a Mendelian form of severe enterocolitis is due to up-regulation of the interleukin-18 (IL18) signaling pathway, and pharmacologic inhibition of IL18 has been shown to reverse this enterocolitis, we undertook a Mendelian randomization study to test the causal effect of elevated IL18 levels on inflammatory bowel disease susceptibility (IBD) in 12,882 cases and 21,770 controls.
|
31253830 |
2019 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Polymorphisms in the NFkB, TNF-alpha, IL-1beta, and IL-18 pathways are associated with response to anti-TNF therapy in Danish patients with inflammatory bowel disease.
|
30811631 |
2019 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IL-33 and IL-18 in Inflammatory Bowel Disease Etiology and Microbial Interactions.
|
31139196 |
2019 |
Inflammatory Bowel Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Inflammatory bowel disease (IBD) is associated with enhanced levels of the IL-1 family cytokines IL-1β and IL-18, which are activated by the Nlrp3 inflammasome.
|
29515025 |
2018 |
Inflammatory Bowel Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Strategies to increase activity of MEFV or IL18 might be developed for the treatment of IBD and prevention of colitis-associated tumorigenesis.
|
29203393 |
2018 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Eight functional SNPs were associated with anti-TNF response either among patients with CD (TLR5 (rs5744174) and IFNGR2 (rs8126756)), UC (IL12B (rs3212217), IL18 (rs1946518), IFNGR1 (rs2234711), TBX21 (rs17250932) and JAK2 (rs12343867)) or in the combined cohort of patient with CD and UC (IBD) (NLRP3 (rs10754558), IL12B (rs3212217) and IFNGR1 (rs2234711)) (P<0.05).
|
28139755 |
2018 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Although the exact aetiology of IBD is unknown, uncontrolled NLRP3 Inflammasome activation has shown to play a major role in the chronic intestinal inflammation and mature IL-1β and IL18 are consistently associated with increased colitis and colitis associated colorectal cancer development.
|
28155620 |
2017 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, recent results indicate that the TLR-2 → NLRP3 → caspase-1 → IL-18 axis is critical to H. pylori-specific immune regulation conferring protection against allergen-induced asthma and inflammatory bowel disease in murine models.
|
27460807 |
2016 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In this review, we focus on IL-18 biology and physiological roles in animal models and human IBD, to provide an outline for development of IL-18 blockade strategies.
|
23651166 |
2013 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
It remains to be determined precisely how the IL-18 alleles influence the pathogenesis of IBD.
|
21273776 |
2011 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, numerous new genes have been identified as being involved in the genetic susceptibility to IBD: TNF-308A, CARD15 (NOD2), MIF-173, N-acetyltransferase 2 (NAT2), NKG2D (natural killer cell 2D), STAT6 (signal transducer and activator of transcription 6), CTLA-4 (cytotoxic T lymphocyte antigen-4), MICA-MICB (major histocompatibility complex A and B), HLA-DRB1, HLA class-II, IL-18, IL-4, MICA-A5, CD14, TLR4, Fas-670, p53 and NF-kappaB.
|
19230040 |
2009 |
Inflammatory Bowel Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To determine the physiological significance of the interactions of meprins with proIL-18, an experimental model of IBD was produced by administering dextran sulfate sodium (DSS) to wild-type and meprin beta knock-out (betaKO) mice, and the serum levels of active IL-18 were determined.
|
18786924 |
2008 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, numerous new genes have been identified to be involved in the genetic susceptibility to IBD: NOD1/Caspase-activation recruitment domains 4 (CARD4), Chemokine ligand 20 (CCL20), IL-11, and IL-18 among others.
|
17948929 |
2007 |
Inflammatory Bowel Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
IL-18 and IL-18 bp messenger RNA (mRNA) expression in colonic mucosa from patients with active CD (n = 72), active ulcerative colitis (UC; n = 32), and non-IBD controls (infectious colitis or diverticulitis; n = 19) and normal, non-diseased controls (n = 20) were measured by reverse-transcribed real-time polymerase chain reaction.
|
17318554 |
2007 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This study sought to investigate associations of IL-18 polymorphisms in inflammatory bowel disease and CD according to CARD15/NOD2 mutation status and clinical phenotypes.
|
16306764 |
2005 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
It was concluded that SNPs at the 5'-end of IL-18 gene might be closely related to the etiology of IBD.
|
15663745 |
2005 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The aim of this study was to determine whether the -137 (G/C) IL-18 promoter polymorphism was associated with IBD susceptibility.
|
16316892 |
2005 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), recent evidence suggests that IL-18 is involved in the pathogenesis.
|
16306765 |
2005 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, interleukin 18, cloned as a novel proinflammatory cytokine, has been implicated in inflammatory bowel disease, especially Crohn's disease.
|
12572878 |
2002 |