IL18, interleukin 18, 3606

N. diseases: 750; N. variants: 18
Disease: Mental deterioration ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0234985
Disease: Mental deterioration
Mental deterioration 		0.020 Biomarker phenotype BEFREE Furthermore, a significant correlation between IL-18 production and cognitive decline was observed in AD patients. 17988833 2008
CUI: C0234985
Disease: Mental deterioration
Mental deterioration 		0.020 GeneticVariation phenotype BEFREE Finally, in a 2 year follow-up study, the -137 CC genotype was strongly and specifically associated with a faster cognitive decline (F = 4.024; df = 4,192; p = 0.0037 for time by IL-18 -137 G/C group interaction) with no interaction effect with the apolipoprotein E epsilon4/non-epsilon4 allele presence. 17299019 2007