IL18, interleukin 18, 3606

N. diseases: 750; N. variants: 18
Disease: Adult Lymphoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma 		0.040 Biomarker disease BEFREE A phase I study of recombinant human (rh) IL-18 given with ofatumumab was undertaken in patients with CD20 lymphoma who had undergone high-dose chemotherapy and autologous peripheral blood stem cell transplantation. 29517616 2018
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma 		0.040 AlteredExpression disease BEFREE We found that SS patients at high risk for lymphoma and those with established lymphoma display high serum cf-DNA levels, substantial extranuclear DNA accumulations in PBMC and SG tissues, a unique NLRP3 inflammasome gene signature in PBMC, and significantly increased serum IL-18 and ASC levels. 29551295 2018
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma 		0.040 AlteredExpression disease BEFREE The mRNA and plasma expression levels of IL-18 were significantly elevated in primary lymphoma patients and decreased after remission. 29312552 2017
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma 		0.040 AlteredExpression disease BEFREE B-CLL and BL cells did not produce bioactive IL-18; and (d) lymphoma B cells displayed heterogeneous expression of either or both IL-18R chain mRNA. 14734463 2004