ILK, integrin linked kinase, 3611

N. diseases: 192; N. variants: 0
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.060 Biomarker disease BEFREE Finally, we observed a tumor-promoting effect of Tspan8 in vivo and a mutually exclusive expression pattern between Tspan8 and phosphorylated ILK in melanoma xenografts and human melanocytic lesions. 28188308 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.060 Biomarker disease BEFREE JWA has an important role in ING4-regulated melanoma angiogenesis, and ING4/JWA/ILK are promising prognostic markers and may be used as anti-angiogenic therapeutic targets for melanoma. 24157826 2013
CUI: C0025202
Disease: melanoma
melanoma 		0.060 Biomarker disease BEFREE Moreover, we found a significant negative correlation between JWA and ILK in melanoma biopsies, and their concomitant expression was closely correlated with melanoma patient survival (P = 0.004), further indicating the regulation of ILK expression by JWA is critical in melanoma. 24064223 2013
CUI: C0025202
Disease: melanoma
melanoma 		0.060 Biomarker disease BEFREE However, the molecular mechanism by which ILK enhances melanoma progression is currently unknown. 21278793 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.060 Biomarker disease LHGDN Moreover, ILK knockdown significantly impaired the growth of melanoma xenografts in severe combined immunodeficient mice. 17575101 2007
CUI: C0025202
Disease: melanoma
melanoma 		0.060 AlteredExpression disease LHGDN Strong ILK expression was observed in 0, 22, 33, and 63% in melanoma biopsies </=0.75, 0.76-1.50, 1.51-3.0, and >3.0 mm in thickness, respectively. 14555513 2003