ILK, integrin linked kinase, 3611

N. diseases: 192; N. variants: 0
Disease: Sarcopenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0872084
Disease: Sarcopenia
Sarcopenia 		0.010 AlteredExpression phenotype BEFREE In conclusion, we propose that hyperphosphatemia induces senescence in cultured myoblasts through ILK overexpression, reducing their proliferative capacity, which could be a mechanism involved in the development of sarcopenia, since old mice showed loss of muscular strength correlated with high serum phosphate concentration and increased levels of ILK and p53. 30271655 2018