Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
As clinical data points to a strong association between depression and motivational alterations, we sought to (1) characterize the motivational changes that are associated with inflammation in mice, and (2) determine if they depend on inflammation-induced activation of indoleamine 2,3 dioxygenase-1 (IDO1).
|
29760410 |
2019 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We hypothesized that GM-CSF could exert antidepressant effects through IDO downregulation in a model for acute inflammation-induced depression.
|
31153376 |
2019 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In this study, we treated male and female 3xTg-AD and wild-type mice with the novel IDO inhibitor DWG-1036 (80 mg/kg) or vehicle (distilled water) from 2 to 6 months of age and then tested them in a battery of behavioral tests that measured spatial learning and memory (Barnes maze), working memory (trace fear conditioning), motor coordination and learning (rotarod), anxiety (elevated plus maze), and depression (tail suspension test).
|
31607909 |
2019 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Body image dissatisfaction is strongly associated with inflammation and mucosa-derived IDO activation independently from depression, pregnancy, BMI and age.
|
27427239 |
2018 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Finally, this review is also directed toward assessing whether IDO and TDO are potential therapeutic target in depression associated with other diseases such as diabetes and/or cancer, as well as the development of potent IDO and TDO inhibitors.
|
30014175 |
2018 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The kynurenine pathway (KP) and its rate-limiting tryptophan degrading enzyme, indolamine 2,3 dioxygenase (IDO), have been implicated in the pathogenesis of depression.
|
29787958 |
2018 |
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In conclusion, the present data show for the first time that resolution of inflammation-induced depression is an active process requiring T lymphocytes acting via an IL-10-dependent pathway to decrease Ido1 expression in the brain.
|
30054585 |
2018 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In this work, we assessed the relationship between single-nucleotide polymorphisms (SNPs) of KAT1, KAT2 and IDO1 gene encoding, and the risk of depression development.
|
29777939 |
2018 |
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Considering a recognized role of the Kynurenine Pathway in depression, we investigated the potential for Desip to alter expression of rate-limiting enzymes of this pathway: indoleamine-2,3-dioxygenases (Ido1 and Ido2).
|
28212884 |
2017 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Hence, this study was envisaged to evaluate the dose dependent inhibition of indoleamine 2,3-dioxygenase (IDO) enzyme employing quercetin (screened employing in vitro method) with levetiracetam for combined management of epilepsy and comorbid depression.
|
28065794 |
2017 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Indolamine 2, 3 dioxygenase (IDO) pathway is considered to be an important pathway in pro-inflammatory cytokine associated stress-induced depression.
|
28911850 |
2017 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In this study, we investigated whether indoleamine 2,3-dioxygenase1 (IDO1)-mediated tryptophan (TRP) metabolism plays a critical role in depression occurring as a side effect of IFN-α therapy.
|
27436416 |
2016 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results reveal an IDO1-mediated regulatory mechanism underlying the comorbidity of pain and depression and suggest a new strategy for the concurrent treatment of both conditions via modulation of brain IDO1 activity.
|
22751107 |
2012 |
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
IDO expression is driven by inflammatory cytokines, and has been suggested as the link between inflammation and a serotonergic deficit in depression.
|
22683764 |
2012 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Although the indoleamine 2,3-dioxygenase (IDO) enzyme seems to be involved in the pathophysiology of IFN-α-induced depression, no pharmacogenetic study has investigated whether variation in the IDO gene modifies vulnerability to this adverse effect.
|
21693183 |
2011 |