|
Squamous cell carcinoma of the head and neck
|
0.710 |
Biomarker
|
disease |
BEFREE |
Because ING1 resides on the long arm of chromosome 13 (13q34) (a region frequently deleted in many tumor types), we sought to characterize its role in head and neck squamous-cell carcinoma (HNSCC).
|
10679922 |
2000 |
|
Malignant neoplasm of stomach
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
A significant decrease in p33(ING1) expression was evident in 15 of 20 gastric cancers.
|
10660101 |
1999 |
|
Malignant neoplasm of stomach
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
However, there has been no report on the prognostic significance of the ING1 expression level in human cancers, though the expression of the wild-type ING1 gene is significantly decreased in breast, lymphoid and gastric cancers as compared with their corresponding normal tissues.
|
15375504 |
2004 |
|
Squamous cell carcinoma
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas.
|
10866301 |
2000 |
|
Squamous cell carcinoma
|
0.160 |
AlteredExpression
|
disease |
BEFREE |
Twenty-six of 28 oral squamous cell carcinomas (SCCs) expressed p33ING1 mRNA.
|
12063558 |
2002 |
|
Squamous cell carcinoma
|
0.160 |
AlteredExpression
|
disease |
BEFREE |
GAPDH mRNA expression was detectable in 12 out of 21 oral squamous cell carcinoma (SCC) samples. p21WAF1 mRNA expression was detectable in 5 out of 12 SCC samples, MDM2 mRNA expression was detectable in 5 our of 12 SCC samples and p33ING1 mRNA expression was detectable in 6 out of 12 SCC samples.
|
12926130 |
2003 |
|
Squamous cell carcinoma
|
0.160 |
Biomarker
|
disease |
BEFREE |
Nuclear entrapment of p33ING1b by inhibition of exportin-1: A trigger of apoptosis in head and neck squamous cell cancer.
|
29729696 |
2018 |
|
Squamous cell carcinoma
|
0.160 |
Biomarker
|
disease |
BEFREE |
Mutational analysis of the candidate tumor suppressor gene ING1 in Indian oral squamous cell carcinoma.
|
11287275 |
2001 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These findings suggest that Src may play a major role in regulating ING1 levels during tumorigenesis in those cancers in which high levels of Src expression or activity are present.
|
23585863 |
2013 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This study suggests that neither perturbation of alternative splicing, nor mutation of p33/ING1 plays a significant role in the development of haematological malignancies.
|
12008079 |
2002 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
ING1 overexpression also blocked cancer cell metastasis in vivo and eliminated tumor-induced mortality in mouse models.
|
24962136 |
2014 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
No ING1 mutations in human brain tumours but reduced expression in high malignancy grades of astrocytoma.
|
14961591 |
2004 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However no significant TSG activity of ING1 was observed while higher activity was reported in different cancer types.
|
25324173 |
2015 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, in a comparison between the cancer and matched normal tissues, a significant decrease in ING1 mRNA expression was found in 17 of 24 (70.8%) breast cancer tissues.
|
10754201 |
2000 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our previous studies using tumor samples from patients have shown that ING1 levels are downregulated in glioblastoma multiforme (GBM), one of the most highly vascularized malignancies.
|
20066899 |
2009 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear.
|
18381585 |
2008 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Decreased expression of p33ING1 mRNA in lymphoid malignancies.
|
10577281 |
1999 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The reduction of mRNA expression in cancer correlated with decreased p33ING1b protein expression (P < 0.0001).
|
15677627 |
2005 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We have recently shown that the INhibitor of Growth 1 (ING1) tumor suppressor is down-regulated in malignant gliomas and that the decrease of ING1 expression correlates with histological grade of malignancy, suggesting a role for ING1 in the pathogenesis and progression of malignant gliomas.
|
17763999 |
2008 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
It has reported that the expression of p33(ING1) mRNA was decreased in lymphoid malignancies.
|
11835353 |
2002 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear.
|
17918192 |
2008 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
ING1 gene mutation is uncommon in cancer, although the subcellular localisation of p33(INGb1) may have an effect on its function.
|
12835293 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Inhibitor of Growth 1 (ING1) is recognized as candidate tumor suppressor.
|
18450387 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, a potential tumour suppressor gene ING1 (inhibitor of growth 1) was shown to inhibit cell growth and induce apoptosis in the presence of p53.
|
11966686 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that p33(ING1) may not be a major candidate tumor suppressor gene in myeloid leukemias.
|
11835353 |
2002 |