ING1, inhibitor of growth family member 1, 3621

N. diseases: 99; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.710 GeneticVariation disease UNIPROT Of 34 informative cases of head and neck squamous cell carcinoma, 68% of tumors showed loss of heterozygosity at chromosome 13q33-34, where the ING1 gene is located. 10866301 2000
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.160 GeneticVariation disease BEFREE Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas. 10866301 2000
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 GeneticVariation group BEFREE ING1 gene mutation is uncommon in cancer, although the subcellular localisation of p33(INGb1) may have an effect on its function. 12835293 2003
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 GeneticVariation group BEFREE Mutational analysis of the candidate tumor suppressor gene ING1 in Indian oral squamous cell carcinoma. 11287275 2001
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 GeneticVariation group BEFREE Furthermore, our data indicate that patients that harbor ING1 mutations in the tumors have a higher risk to die from the disease within 5 years (50%) compared to patients with no ING1 mutation (18%). 15201991 2004
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 GeneticVariation group BEFREE ING genes (ING1-5) were identified has tumor suppressor genes. 24333729 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 GeneticVariation group BEFREE Here we present the first report that three missense mutations and three silent changes were detected in the ING1 gene in 6 of 23 tumors with allelic loss at the 13q33-34 region. 10866301 2000
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 GeneticVariation group BEFREE We then determined the genomic structure of the ING1 gene and sequenced the entire coding region in 20 primary tumors showing 13q LOH and in five head and neck cancer cell lines. 10679922 2000
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 GeneticVariation group BEFREE Furthermore, the micron-sized MCT adjuvant was as potent as B type CpGs and clearly superior to the commonly used Alum adjuvant when total CD8<sup>+</sup>, specific p33 T cell response or tumour protection were assessed. 31027511 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.090 GeneticVariation group BEFREE ING1 gene mutation is uncommon in cancer, although the subcellular localisation of p33(INGb1) may have an effect on its function. 12835293 2003
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.060 GeneticVariation phenotype BEFREE Our study demonstrates that overexpression of let-7b in gastric cancer can inhibit invasion and migration of gastric cancer cells through directly targeting the tumor metastasis-associated gene ING1. 25613480 2015
CUI: C0025202
Disease: melanoma
melanoma 		0.050 GeneticVariation disease BEFREE p33ING1b mutations in melanoma are rare. 16792758 2006
CUI: C0025202
Disease: melanoma
melanoma 		0.050 GeneticVariation disease LHGDN We show that 20% of the melanoma primaries contained missense mutations in the SAP30-interacting domain and PHD finger motif of the ING1 gene with the R102L and N260S alterations observed more than once. 15201991 2004
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.040 GeneticVariation disease BEFREE Interestingly, a rearrangement of the ING1 gene was found in a neuroblastoma cell line, supporting its involvement in tumor development. 10679922 2000
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.030 GeneticVariation disease BEFREE Genetic alterations of tumor suppressor ING1 in human non-small cell lung cancer. 21286670 2011
CUI: C0278996
Disease: Malignant Head and Neck Neoplasm
Malignant Head and Neck Neoplasm 		0.030 GeneticVariation disease BEFREE We then determined the genomic structure of the ING1 gene and sequenced the entire coding region in 20 primary tumors showing 13q LOH and in five head and neck cancer cell lines. 10679922 2000
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.030 GeneticVariation disease BEFREE Interestingly, a rearrangement of the ING1 gene was found in a neuroblastoma cell line, supporting its involvement in tumor development. 10679922 2000
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.030 GeneticVariation disease BEFREE Recently, three ING1 splice variants have been cloned, but their roles in apoptosis and p53 regulation in human hepatocellular carcinoma (HCC) have not been fully elucidated. 19085961 2009
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma 		0.030 GeneticVariation disease BEFREE We then determined the genomic structure of the ING1 gene and sequenced the entire coding region in 20 primary tumors showing 13q LOH and in five head and neck cancer cell lines. 10679922 2000
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.030 GeneticVariation disease BEFREE Interestingly, a rearrangement of the ING1 gene was found in a neuroblastoma cell line, supporting its involvement in tumor development. 10679922 2000
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.020 GeneticVariation disease BEFREE We discuss the functional association linking p53, IGF-1, SIRT1, and ING-1 splice variants with senescence and aging, and review a selection of splicing defects occurring in accelerated aging (progeria), vascular aging, and Alzheimer's disease. 28703423 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.020 GeneticVariation disease BEFREE No mutation of ING1 gene is found, and there are only few LOH in sporadic colorectal cancers. 16273637 2005
CUI: C0018203
Disease: Chronic granulomatous disease
Chronic granulomatous disease 		0.020 GeneticVariation group BEFREE A male CGD patient with pg91(phox) deficiency exhibited a trend toward prolongation of this calcium response, whereas two other CGD patients (one with p47 and one with 67(phox) deficiencies) had normal calcium transients. 15527168 2004
CUI: C0033300
Disease: Progeria
Progeria 		0.020 GeneticVariation disease BEFREE We discuss the functional association linking p53, IGF-1, SIRT1, and ING-1 splice variants with senescence and aging, and review a selection of splicing defects occurring in accelerated aging (progeria), vascular aging, and Alzheimer's disease. 28703423 2017
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.020 GeneticVariation disease BEFREE Thus, ING1 mutation is very rare in breast or ovarian cancers, however, repression of ING1 expression frequently accompanies tumour development of breast cancer. 10498868 1999