|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We found that vaccination against recombinant mouse inhibin-α provides protection and therapy against transplantable I-10 mouse TSC tumors in male BALB/c mice.
|
28428886 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The inhibin-α gene was identified as a tumor suppressor gene in the gonads and adrenal glands by functional studies using knockout mice.
|
28260095 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Specific inbred strains and transgenic inhibin-α Simian Virus 40 T antigen (inhα/Tag) mice are genetically susceptible to gonadectomy-induced adrenocortical neoplasias.
|
28131743 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The INHA subunit is up-regulated in most human ovarian and testicular cancers but knock-out studies in mice showed the INHA subunit is a tumour suppressor with gonadal and adrenal specificity.
|
25180271 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We conclude that the factors driving INHA expression are reduced in ACCs with poor outcome, implicating a role for INHA as a tumor suppressor in humans.
|
23866946 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Hecate-CGbeta conjugate and gonadotropin suppression shows two distinct mechanisms of action in the treatment of adrenocortical tumors in transgenic mice expressing Simian Virus 40 T antigen under inhibin-alpha promoter.
|
19261682 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Gene-knockout studies in mice suggest that INHA, encoding a subunit of gonadotropin-regulating proteins known as inhibins, is a tumor suppressor for testicular stromal cell tumors.
|
18413775 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Inhibin alpha-subunit expression was much weaker in the glands of tumours than in non-neoplastic specimens.
|
15745937 |
2005 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Transgenic mice with an inhibin alpha subunit gene deletion develop stromal/granulosa cell tumours suggesting that the alpha subunit is a tumour suppressor gene.
|
15027884 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We propose that the tumor suppressor activities of the inhibin alpha subunit dominate in non-malignant tissue, but its oncogenic activities emerge during tumorigenesis.
|
15451570 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The data demonstrate that promoter methylation is associated with downregulation of the INHA gene in prostate cancer cell lines, which is consistent with its tumour suppressive role.
|
14765992 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumour-suppressive inhibin alpha is then silenced as the tumour progresses but is reactivated as a pro-metastatic factor in advanced, aggressive cancers.
|
15450247 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Castrated inhibin alpha knockout mice develop sex steroidogenic adrenal cortical tumors.
|
12760377 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
For example, while inhibin (alpha subunit) is proposed to be a tumor suppressor in some types of ovarian cancer, activin appears to stimulate tumor development.
|
12366660 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Transgenic studies assigned a tumor-suppressive role to the inhibin alpha-subunit, and in human prostate cancer inhibin alpha-subunit gene expression was down-regulated.
|
11818495 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the percentage of inhibin alpha-positive cells varied greatly in different tumour types.
|
10810286 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Abundant expression of the inhibin alpha subunit gene was observed in the GCT and to a lesser extent in the mucinous and serous tumors. beta subunit expression was also present in the GCT and to a lesser extent in the other tumors.
|
10329046 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
When gonadectomized, inhibin alpha/SV40 T-antigen transgenic mice develop adrenocortical tumors in a gonadotropin-dependent fashion.
|
10449810 |
1999 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In contrast, functional deletion of the inhibin alpha gene in male and female mice results in the development of primary gonadal granulosa/Sertoli cell tumors.
|
9506758 |
1998 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Transgenic (TG) mice, expressing the Simian Virus 40 T-antigen (Tag) under a 6-kb fragment of the murine inhibin alpha-subunit promoter (inh alpha p), develop gonadal tumors of granulosa/theca or Leydig cell origin.
|
9626655 |
1998 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast, inhibin alpha subunit mRNA was expressed in 60%, 50%, 75%, and 75% of the tumors in groups 1, 2, 3 and 4, respectively, whereas ACTR II mRNA was demonstrated in 20%, 37.5%, 62.5% and 50% of the tumors in each group.
|
7670558 |
1995 |