|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Examination of the interactions has shown that many of the key residues for inhibitor binding were found in mutations of the InhA gene in the isoniazid-resistant Mycobacterium tuberculosis.
|
30501592 |
2020 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Taken together, our results demonstrated that PAS resistance and mutations in katG, inhA promoter or oxyR-ahpC intergenic region in INH resistant M. tuberculosis has little effect on pasiniazid susceptibility.
|
31425771 |
2020 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Molecular docking and Molecular dynamics studies were helped in revealing the mode of action of these compounds through their interactions with the active site of the Mycobacterium tuberculosis enoyl reductase (InhA) enzyme.
|
31129451 |
2019 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, molecular epidemiological characteristics associated with INH resistance mutations in Mycobacterium tuberculosis in codon katG315 and in the promoter region of the inhA gene were investigated.
|
29604431 |
2018 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The mutations of katG and inhA genes of isoniazid-resistant Mycobacterium tuberculosis isolates in Taiwan.
|
24184004 |
2015 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The MeltPro TB/INH assay, recently approved by the Chinese Food and Drug Administration, is a closed-tube, dual-color, melting curve analysis-based, real-time PCR test specially designed to detect 30 isoniazid (INH) resistance mutations in katG position 315 (katG 315), the inhA promoter (positions -17 to -8), inhA position 94, and the ahpC promoter (positions -44 to -30 and -15 to 3) of Mycobacterium tuberculosis.
|
24599986 |
2014 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This result suggests that mutations in the rpoB531, katGSer315Thr, and C-15T in the inhA promoter region, and gyrA94, embB306, pncA159, rpsL43, and A1401G in the rrs gene could serve as useful markers for rapid detection of resistance profile in the clinical isolates of M. tuberculosis in Korea, with potentials for the new therapeutic benefits in actual clinical practice.
|
23561273 |
2013 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the molecular and epidemiological characteristics and the association with first-line treatment outcomes of the main isoniazid resistance mutations in Mycobacterium tuberculosis in codon 315 of the katG and in the promoter region of the inhA gene.
|
23689727 |
2013 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the Mycobacterium (M.) tuberculosis bacterial genome, such as those to the rpoB gene and mabA-inhA promoter region, have been linked to TB drug resistance in against rifampicin and isoniazid, respectively.
|
22884688 |
2012 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aims of this study were to determine the frequency of MTb and NTM species in HIV-infected patients from Mexico City, to evaluate the genotypic diversity of the Mycobacterium tuberculosis complex strains, to determine their drug resistance profiles by colorimetric microplate Alamar Blue assay (MABA), and finally, to detect mutations present in katG, rpoB and inhA genes, resulting in isoniazid (INH) and rifampin (RIF) resistance.
|
20236539 |
2010 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Detection of rpoB, katG and inhA gene mutations in Mycobacterium tuberculosis clinical isolates from Chongqing as determined by microarray.
|
20491829 |
2010 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rolling circle amplification and multiplex allele-specific PCR for rapid detection of katG and inhA gene mutations in Mycobacterium tuberculosis.
|
19604720 |
2009 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We, therefore, conducted a comprehensive evaluation of INH resistant M. tuberculosis strains (n = 224) from three South American countries with high burden of drug resistant TB to characterize mutations in katG, ahpC and inhA gene loci and correlate with minimal inhibitory concentrations (MIC) levels and spoligotype strain family.
|
19228426 |
2009 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Molecular analysis of the loci of rpoB and katG genes and the inhA promoter region of 412 M. tuberculosis clinical isolates from various parts of the Russian Federation was carried out.
|
17442757 |
2007 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
katG and inhA genes from isoniazid-resistant Mycobacterium tuberculosis strains isolated in Finland were examined by PCR or sequencing.
|
8878604 |
1996 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These studies further support the association between katG and inhA gene mutations and isoniazid resistance in M. tuberculosis, while also suggesting that other undefined mechanisms of isoniazid resistance exist.
|
8585728 |
1995 |