Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, significant association was observed between i) circulating IP-10 levels and time to Mycobacterium Growth Indicator Tube (MGIT) culture conversion (p =0.032); ii) smear grade among active TB patients and circulating IP-10 levels (p =0 .032).
|
31678649 |
2020 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, it was observed that nicotine decreases the production of interleukin (IL)-6 and C-C chemokine ligand (CCL)5 during Mtb infection in epithelial cells (EpCs), whereas in macrophages derived from human monocytes (MDMs) there is a decrease in IL-8, IL-6, tumor necrosis factor (TNF)-α, IL-10, CCL2, C-X-C chemokine ligand (CXCL)9 and CXCL10 only during infection with Mtb.
|
31631328 |
2020 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IP-10 was independently associated with increased odds of TB; OR 4.2, p=0.009.
|
31689350 |
2020 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A number of studies have evaluated the use of interferon-γ-induced protein 10 (IP-10), which is elevated after tuberculosis infection, as a biomarker for LTBI, but conclusive results regarding its effectiveness have not been reported.
|
30553864 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study shows that IP-10 is a potential biomarker for differentiating active tuberculosis from latent tuberculosis.
|
31388072 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Acute phase proteins and IP-10 as triage tests for the diagnosis of tuberculosis: systematic review and meta-analysis.
|
30076971 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The discriminatory performance of IP-10 following stimulation with recombinant PE35 and PPE68 (assessed by AUC) between TB patients and HCs were similar (AUC: 0.79 [95% CI 0.68-0.89] and 0.79 [95% CI 0.69-0.89], respectively).
|
31564016 |
2019 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, in active TB a decline of total urine IP-10 was observed at therapy completion; agonist/antagonist forms reflected this decline although their differences were not statistically significant.
|
30201505 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IP-10 is elevated in serum of patients with chronic hepatitis C virus (HCV) and tuberculosis (TB) infections, although it remains to be determined the contribution of IP-10 in restricting Mycobacterium tuberculosis (Mtb) replication.
|
31147175 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The combination of IP-10, IFN-γ, ferritin, and 25(OH)D achieved the best diagnostic performance to discriminate between active TB and LTBI cases in children in relation to the area under receiver operating characteristic (ROC) curve 0.955 (confidence interval 95%: 0.91-1.00), achieving optimal sensitivity and specificity for the development of a new test (93.2 and 90.0%, respectively).
|
31474956 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Before ART initiation, high HIV viral load was associated with elevated CXCL10 and tuberculosis coinfection was associated with elevated soluble CD14.
|
31086991 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study aims to synthesis and analysis the diagnostic value of IP-10 for children TB.
|
31169732 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, direct analysis of the serum components of the IL-18/IL-37 signalling complex and IP-10 may be applicable in designing novel diagnostic tests for ATB.
|
31821340 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We traced the source of CXCL10 secretion using immunohistochemical and confocal analysis to multinucleated giant cells in the TB lesions, and variable expression by macrophages.
|
30026741 |
2018 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In -135G/A (rs56061981) polymorphism, PTB patients with GG genotype showed a significantly decreased expression of CD3+ CXCL10+ and CD3+ CD4+ CXCL10+ T cells compared to A allele carrier (GA+AA) under unstimulated, CFA induced and M. tuberculosis infected cultures (P<0.05).
|
28336310 |
2018 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Urine interferon gamma inducible protein 10 (IP-10) is a potential biomarker of treatment response in chronic hepatitis C virus infection and lung diseases, including tuberculosis.
|
29843631 |
2018 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, increased IP-10 in response to TB1 was found in subjects with LTBI compared to those with active TB.
|
30029901 |
2018 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Plasma level of CXCL10 is predictive of the active phase of TB infection.
|
29559124 |
2018 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Gene expression of FcGR1A and BATF2, and plasma protein levels of IFNγ and CXCL10 have the potential to independently detect TB in advanced HIV.
|
29764370 |
2018 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
As a second example we will describe the use of CXCL10 as a disease biomarker in Tuberculosis, highlighting findings from human and mouse studies that should be considered in veterinary research.
|
30290889 |
2018 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we investigate the early response in IP-10 levels (between day 0 and day 7 of TB therapy) to identify bacteriological status at diagnosis among 127 HIV-infected patients starting TB treatment.
|
29084992 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increased age and HIV co-infection were associated with decreased cytokine induction, and especially IL-21 and IP-10 were less prevalent in HIV co-infected children with tuberculosis.
|
28299430 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further analysis showed that positive correlation between IP-10 and IFN-<i>γ</i> existed in healthy and tuberculosis monkeys.
|
28512637 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IP-10 is a chemokine and inflammatory factor that is associated with such diseases as tuberculosis, hepatitis B virus, and pancreatic cancer.
|
28465448 |
2017 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To study single nucleotide polymorphisms (SNPs) of chemokine genes CCL2, CXCL9, CXCL10 and CXCL11, and their association with TB susceptibility.
|
27510253 |
2016 |