Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
CTD_human |
Hyperproinsulinemia in a family with a proposed defect in conversion is linked to the insulin gene.
|
2991050 |
1985 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
CTD_human |
Diabetes due to secretion of a structurally abnormal insulin (insulin Wakayama). Clinical and functional characteristics of [LeuA3] insulin.
|
3511099 |
1986 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
CTD_human |
Posttranslational cleavage of proinsulin is blocked by a point mutation in familial hyperproinsulinemia.
|
4019786 |
1985 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
CTD_human |
Familial hyperproinsulinemia due to a proposed defect in conversion of proinsulin to insulin.
|
6382002 |
1984 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data suggest that both increased insulin resistance and abnormal processing of proinsulin are present in offspring of parents with diabetes.
|
7556950 |
1995 |
Hyperinsulinism
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Non-insulin-treated subjects with the DD genotype had increased insulin sensitivity by HOMA % (DD 56.4%, II 29.4%, P = .027) and lower levels of des 31,32 proinsulin (DD 3.3, II 7.6 pmol.L-1, P = .012) compared with II subjects.
|
8521557 |
1995 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results show that FDR of NIDDM patients have true hyperinsulinemia (which is not a consequence of cross-reactivity with proinsulin) and hyperproinsulinemia and no dysfunction of a qualitative nature in beta-cells.
|
10347771 |
1999 |
Hyperinsulinism
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Polymorphisms in candidate genes for type 2 diabetes mellitus in a Mexican population with metabolic syndrome findings.
|
14693412 |
2004 |
Hyperinsulinism
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Although all family members were obese, and hyperinsulinemia with high proinsulin and C-peptide was found in all except one sibling, only the mother and one child had overt type 2 diabetes mellitus.
|
15142366 |
2004 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
LHGDN |
Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus.
|
15538935 |
2004 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
The INS-VNTR class III is more frequent in women who develop GDM, and may be associated with decreased ability of the beta cell to meet the increased insulin requirements as reflected by the need for insulin supplementation for adequate glycaemic control.
|
17011062 |
2007 |
Hyperinsulinism
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In French obese children, INS VNTR did not associate with fasting insulin levels (P = 0.23) and class I allele showed only borderline association with increased insulin secretion index at 30 min (P = 0.03).
|
18388898 |
2008 |
Hyperinsulinism
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Leptin, insulin, and glucose serum levels in large-for-gestational-age infants of diabetic and non-diabetic mothers.
|
18404969 |
2008 |
Hyperinsulinism
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
PE cells co-cultured with islet cells or islet cell-derived conditioned medium (CM) showed increased expression levels of β-cell markers; significantly higher levels of proinsulin- and Newport Green (NG)-positive cells, which revealed the characteristics of insulin producing cells; and increased insulin secretion upon glucose stimulation.
|
25173880 |
2015 |
Hyperinsulinism
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Another monogenic diabetes gene, the preproinsulin gene (INS), is unique in that INS mutations can cause hyperinsulinemia, hyperproinsulinemia, neonatal diabetes mellitus, one type of maturity-onset diabetes of the young (MODY10), and autoantibody-negative T1D.
|
27035557 |
2016 |
Hyperinsulinism
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
After 4-week continuous exposure, a hypoglycaemic property of Netrin-1 was demonstrated, which is probably attributable to improved β-cell function, shown as increased insulin content and preproinsulin mRNA expression.
|
27520508 |
2016 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, metformin combined with exercise training reduced circulating proinsulin, and both groups taking metformin increased insulin clearance.
|
28473613 |
2017 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
Further, our data demonstrate that whole-body insulin resistance is associated with underlying defects in proinsulin secretion, which become detectable only in the presence of increased insulin secretion demand.
|
30131390 |
2018 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
Conversely, RILP depletion sustained proinsulin and increased insulin secretion.
|
31624142 |
2020 |