Diabetes, Autoimmune
|
0.590 |
Biomarker
|
disease |
BEFREE |
HLA-DR3-DQ2<sup>+</sup>huCD4<sup>+</sup>IA/IE<sup>-/-</sup>RIP.B7.1<sup>+</sup> mice spontaneously developed autoimmune diabetes (incidence 46% by 35 weeks of age), accompanied by numerous hallmarks of human type 1 diabetes (autoantibodies against GAD65 and proinsulin; pancreatic islet infiltration by CD4<sup>+</sup>, CD8<sup>+</sup> B220<sup>+</sup>, CD11b<sup>+</sup> and CD11c<sup>+</sup> immune cells).
|
31612266 |
2019 |
Diabetes, Autoimmune
|
0.590 |
Biomarker
|
disease |
BEFREE |
Strikingly, adoptive transfer of miR-183 and miR-96 overexpressing antigen-specific T cells into INS-HA/Rag2KO mice accelerated the development of autoimmune diabetes, whereas transfer of antagomiR-treated cells delayed the disease onset.
|
30201436 |
2019 |
Diabetes, Autoimmune
|
0.590 |
Biomarker
|
disease |
CTD_mouse |
Inhibition of SREBP With Fatostatin Does Not Attenuate Early Diabetic Nephropathy in Male Mice.
|
29420703 |
2018 |
Diabetes, Autoimmune
|
0.590 |
Biomarker
|
disease |
BEFREE |
Among 85 selected CD4 TCRs tested for reactivity to preproinsulin peptides presented by diabetes-susceptible HLA-DQ and HLA-DR molecules, one T cell recognized C-peptide amino acids 19-35, and two clones from separate donors responded to insulin B-chain amino acids 9-23 (B:9-23), which are known to be a critical self-antigen-driving disease progress in animal models of autoimmune diabetes.
|
27920090 |
2017 |
Diabetes, Autoimmune
|
0.590 |
Biomarker
|
disease |
BEFREE |
Materno-Fetal Transfer of Preproinsulin Through the Neonatal Fc Receptor Prevents Autoimmune Diabetes.
|
25918233 |
2015 |
Diabetes, Autoimmune
|
0.590 |
GeneticVariation
|
disease |
BEFREE |
PTPN22 (1p13.2), STAT4 (2q32.2), CTLA4 (2q33.2), HLA (6p21), IL2RA (10p15.1), INS (11p15.5), ERBB3 (12q13.2), SH2B3 (12q24.12), and CLEC16A (16p13.13) were convincingly associated with autoimmune diabetes in adults (P ≤ 0.002), with consistent directions of effect as reported for pediatric type 1 diabetes.
|
21873553 |
2011 |
Diabetes, Autoimmune
|
0.590 |
Therapeutic
|
disease |
CTD_human |
Cortical and hippocampal mitochondria bioenergetics and oxidative status during hyperglycemia and/or insulin-induced hypoglycemia.
|
20620209 |
2010 |
Diabetes, Autoimmune
|
0.590 |
GeneticVariation
|
disease |
BEFREE |
We conclude that short 5'INS VNTR class I alleles play a role in susceptibility to autoimmune diabetes in the context of APECED.
|
20535137 |
2010 |
Diabetes, Autoimmune
|
0.590 |
Biomarker
|
disease |
CTD_mouse |
A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy.
|
17151334 |
2007 |
Diabetes, Autoimmune
|
0.590 |
Biomarker
|
disease |
BEFREE |
Our results of INS VNTR polymorphism in patients with the onset of diabetes after 35 years of age confirm the association of Class I INS VNTR with autoimmune diabetes and the protective effect of Class III INS VNTR on the insulin secretion in GADA-positive subjects.
|
15046555 |
2004 |
Diabetes, Autoimmune
|
0.590 |
Biomarker
|
disease |
BEFREE |
Here, we demonstrate that syngeneic transplantation of hematopoietic stem cells encoding proinsulin transgenically targeted to APCs totally prevents the development of spontaneous autoimmune diabetes in NOD mice.
|
12727927 |
2003 |
Diabetes, Autoimmune
|
0.590 |
Biomarker
|
disease |
BEFREE |
A peptide that spans the junction of the insulin B chain and the connecting (C) peptide in proinsulin has been reported to stimulate T cells from humans at risk for type 1 diabetes and autoimmune diabetes-prone NOD mice.
|
12727928 |
2003 |