|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mice deficient in the myocyte channel aquaporin 7 (AQP7) show significantly reduced glycerol and ATP contents and develop obesity; however, the influence of AQP7 on cardioplegia effectiveness remains unclear.
|
31707553 |
2019 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
AQP7 is expressed in adipose tissue where it facilitates the efflux of glycerol, and AQP7 deficiency has been linked to increased glycerol kinase activity and triglyceride accumulation in adipose tissue, leading to obesity and secondary development of insulin resistance.
|
29300344 |
2018 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The present data suggest the promising therapeutic role of RKs in HF diet-induced obesity that is likely attributable, at least in part, to upregulation of AQP7 expression.
|
29787773 |
2018 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Adipocyte aquaporin 7 (AQP7) expression in lean children and children with obesity. Possible involvement in molecular mechanisms of childhood obesity.
|
30226208 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Aquaporin 7 (AQP7), a unique glycerol permeable integral membrane protein, has been associated with the onset of obesity.
|
28489425 |
2017 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
AQP7-deficient mice develop obesity, insulin resistance, and hyperglyceroluria.
|
22899094 |
2013 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
AQP7 is a glycerol channel in adipose tissue with a suggested role in controlling the accumulation of triglycerides and secondly development of obesity and type-2 diabetes.
|
23001483 |
2012 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
AQP7 transcript levels ratio of SAT vs. VAT changed with the presence of obesity and T2D.
|
20463097 |
2010 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present work was to evaluate the effect of obesity and type 2 diabetes mellitus (T2DM) on gene expression levels of AQP7 in visceral adipose tissue (VAT) and AQP9 in liver.
|
18401671 |
2008 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We examined whether common single nucleotide polymorphisms (SNPs) in the AQP7 gene modulate the risk of obesity and related abnormalities.
|
17351148 |
2007 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our objective was to test the hypothesis that AQP7 gene expression levels may be affected by presence of obesity and type 2 diabetes in humans.
|
17566090 |
2007 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
New studies on AQP7 highlight the important role of glycerol transport in the development of obesity and metabolic disease.
|
16487720 |
2006 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
In summary, our data show that the AQP7 gene is differentially expressed in adipose tissue of lean and obese individuals.
|
16325777 |
2006 |
|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis.
|
17072980 |
2006 |
|
Albuminuria
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic Association of Albuminuria with Cardiometabolic Disease and Blood Pressure.
|
30220432 |
2018 |
|
GLYCEROL QUANTITATIVE TRAIT LOCUS
|
0.100 |
GeneticVariation
|
phenotype |
CLINVAR |
|
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
Biomarker
|
disease |
BEFREE |
Here, the abundance of AQP7 in abdominal subcutaneous adipose tissue (SAT) and skeletal muscle was evaluated in the overnight fasted and postprandial state in eight lean and eight obese men with type 2 diabetes (T2D).
|
29783856 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
We were unable to evidence a link between a low AQP7 abundance in SAT and genetic predisposition type-2 diabetes.
|
23001483 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
AQP7 transcript levels ratio of SAT vs. VAT changed with the presence of obesity and T2D.
|
20463097 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
Biomarker
|
disease |
BEFREE |
The correlation between SAT AQP7 and liver AQP9 was stronger in intolerant and type 2 diabetes mellitus subjects (r = 0.602, P = .011).
|
19615702 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Gene expression levels of AQP7 in VAT showed a tendency toward an increase (P = 0.065) in obese patients (both NG and T2DM) compared to lean subjects.
|
18401671 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Among several SNPs we identified, A-953G in the AQP7 promoter was associated with type 2 diabetes in 977 (530 female/447 male) Caucasians: odds ratio for XG (i.e., AG+GG) versus AA individuals was 1.36 (95% CI 1.01-1.84), P = 0.04.
|
17351148 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Our objective was to test the hypothesis that AQP7 gene expression levels may be affected by presence of obesity and type 2 diabetes in humans.
|
17566090 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
There is increasing evidence that the glycerol channel, aquaporin 7(AQP7), has an important role in adipose tissue formation and function--deletion of the gene in a mouse strain leads to obesity and diabetes type 2 if the mice are aged or fed earlier with a high-fat or sucrose diet.
|
16487720 |
2006 |