PDX1, pancreatic and duodenal homeobox 1, 3651

N. diseases: 185; N. variants: 22
Disease: Fetal Growth Retardation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.310 AlteredExpression phenotype BEFREE Although no significant differences were observed in mRNA level of insulin and PDX-1, the expression of genes related to insulin exocytosis such as munc13-1, vamp-2, syntaxin1a, rab3a were reduced significantly in IUGR newborn rats.IUGR animals were glucose-intolerant. 20225168 2010
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.310 Biomarker phenotype RGD The fetal IUGR state was characterized by loss of USF-1 binding at the proximal promoter of Pdx1, recruitment of the histone deacetylase 1 (HDAC1) and the corepressor Sin3A, and deacetylation of histones H3 and H4. 18464933 2008
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.310 Biomarker phenotype RGD Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat. 12606515 2003
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.310 Biomarker phenotype HPO