PDX1, pancreatic and duodenal homeobox 1, 3651

N. diseases: 185; N. variants: 22
Disease: Pancreatitis, Chronic ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.030 Biomarker disease BEFREE Interferon-γ Decreases Nuclear Localization of Pdx-1 and Triggers β-Cell Dysfunction in Chronic Pancreatitis. 25839229 2015
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.030 GeneticVariation disease BEFREE In the pancreata of Pdx1-Cre; LSL-Kras(G12D) mice, exendin-4 led to acceleration of the disruption of exocrine architecture and chronic pancreatitis with mucinous metaplasia and increased formation of murine PanIN lesions. 22266668 2012
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.030 AlteredExpression disease BEFREE The results indicate that beta-cell dysfunction during progression of CP correlates with the decrease in PDX-1 gene expression. 20467340 2010