PDX1, pancreatic and duodenal homeobox 1, 3651

N. diseases: 185; N. variants: 22
Disease: Impaired insulin secretion ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0948379
Disease: Impaired insulin secretion
Impaired insulin secretion 		0.020 AlteredExpression disease BEFREE Silencing of GPR183 in INS-1 cells decreased the expression of proinsulin genes, Pdx1, Mafa and impaired insulin secretion with a concomitant decrease in cAMP generation. 31550518 2020
CUI: C0948379
Disease: Impaired insulin secretion
Impaired insulin secretion 		0.020 AlteredExpression disease BEFREE Systems biology approaches identified HNF1A, PDX1 and REST as drivers of gene co-expression modules correlated with impaired insulin secretion or glucose tolerance, and 14 out of 19 differentially expressed type 2 diabetic islet signature genes were enriched in these modules. 29185012 2018