PDX1, pancreatic and duodenal homeobox 1, 3651

N. diseases: 185; N. variants: 22
Disease: Secondary Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.020 Biomarker group BEFREE JTC801 was administered by gavage to mice with xenograft tumors, C57BL/6 mice with orthographic pancreatic tumors grown from Pdx1-Cre;KRas<sup>G12D/+</sup>;Tp53<sup>R172H/+</sup> (KPC) cells, mice with metastases following tail-vein injection of KPC cells, and Pdx-1-Cre;Kras<sup>G12D/+</sup> mice crossed with Hmgb1<sup>flox/flox</sup> mice (KCH mice). 29248440 2018
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.020 GeneticVariation group BEFREE During the progression from primary tumors to metastases, the wild-type allele of Kras was progressively lost (loss of heterozygosity at Kras or LOH at Kras) in p16flox/flox; LSL- KrasG12D; Pdx1-Cre mice. 22113502 2011