Disease: Waldenstrom Macroglobulinemia ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024419
Disease: Waldenstrom Macroglobulinemia
Waldenstrom Macroglobulinemia 		0.040 Biomarker disease BEFREE Patient-derived cell lines and primary samples were used in both <i>in vitro</i> and <i>in vivo</i> experiments to model Waldenström's macroglobulinemia and its response to IRAK1/4 inhibitors. 30126942 2018
CUI: C0024419
Disease: Waldenstrom Macroglobulinemia
Waldenstrom Macroglobulinemia 		0.040 Biomarker disease BEFREE Activating <i>MYD88</i> mutations are present in 95% of Waldenström macroglobulinemia (WM) patients, and trigger NF-κB through BTK and IRAK. 30401751 2018
CUI: C0024419
Disease: Waldenstrom Macroglobulinemia
Waldenstrom Macroglobulinemia 		0.040 GeneticVariation disease BEFREE IRAK1 is the binding partner of MyD88, which is mutated in a fraction of Waldenström macroglobulinemia. 25341731 2014
CUI: C0024419
Disease: Waldenstrom Macroglobulinemia
Waldenstrom Macroglobulinemia 		0.040 GeneticVariation disease BEFREE The results establish BTK as a downstream target of MYD88 L265P signaling, and provide a framework for the study of BTK inhibitors alone, and in combination with IRAK inhibitors for the treatment of WM. 23836557 2013