IRF1, interferon regulatory factor 1, 3659

N. diseases: 257; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.660 Biomarker disease HPO
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.660 Biomarker disease CTD_human
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.660 CausalMutation disease CGI
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.650 Biomarker disease GENOMICS_ENGLAND
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.650 CausalMutation disease CGI
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.600 CausalMutation group CLINVAR
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.600 CausalMutation group CGI
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.600 Biomarker group CTD_human
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.380 Biomarker disease GENOMICS_ENGLAND
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.310 Biomarker disease CTD_human
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.310 Biomarker disease GENOMICS_ENGLAND
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.300 Biomarker group CTD_human
CUI: C0153943
Disease: Benign neoplasm of stomach
Benign neoplasm of stomach 		0.300 CausalMutation disease CGI
CUI: C0154060
Disease: Carcinoma in situ of stomach
Carcinoma in situ of stomach 		0.300 CausalMutation disease CGI
CUI: C0496905
Disease: Neoplasm of uncertain or unknown behavior of stomach
Neoplasm of uncertain or unknown behavior of stomach 		0.300 CausalMutation disease CGI
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.300 Biomarker disease CTD_human
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.120 CausalMutation disease CLINVAR
CUI: C0007120
Disease: Bronchioloalveolar Adenocarcinoma
Bronchioloalveolar Adenocarcinoma 		0.100 Biomarker disease HPO
CUI: C0544886
Disease: Somatic mutation
Somatic mutation 		0.100 Biomarker phenotype HPO
CUI: C4703633
Disease: Increased level of L-fucose in urine
Increased level of L-fucose in urine 		0.100 Biomarker phenotype HPO
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.100 AlteredExpression group BEFREE Constitutive expression of an ISGF2/IRF1 transgene leads to interferon-independent activation of interferon-inducible genes and resistance to virus infection. 1376370 1992
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.380 GeneticVariation disease BEFREE We have investigated the allelic loss of IRF1 in a group of 12 patients with MDS and a 5q deletion and 2 patients with AML and a 5q deletion. 8219215 1993
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Recently IRF1, a putative tumor suppressor gene localized to the long arm of chromosome 5, has been shown to be deleted from the 5q- chromosome in a group of patients with MDS and AML. 8219215 1993
CUI: C3463824
Disease: MYELODYSPLASTIC SYNDROME
MYELODYSPLASTIC SYNDROME 		0.100 GeneticVariation group BEFREE We have investigated the allelic loss of IRF1 in a group of 12 patients with MDS and a 5q deletion and 2 patients with AML and a 5q deletion. 8219215 1993
CUI: C3463824
Disease: MYELODYSPLASTIC SYNDROME
MYELODYSPLASTIC SYNDROME 		0.100 Biomarker group BEFREE Thus, IRF-1 may be a critically deleted gene in human leukemia and myelodysplasia. 8438156 1993