IRF1, interferon regulatory factor 1, 3659

N. diseases: 257; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.660 Biomarker disease HPO
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.660 Biomarker disease CTD_human
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.660 CausalMutation disease CGI
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.650 Biomarker disease GENOMICS_ENGLAND
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.650 CausalMutation disease CGI
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.600 CausalMutation group CLINVAR
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.600 CausalMutation group CGI
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.600 Biomarker group CTD_human
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.380 Biomarker disease GENOMICS_ENGLAND
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.310 Biomarker disease CTD_human
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.310 Biomarker disease GENOMICS_ENGLAND
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.300 Biomarker group CTD_human
CUI: C0153943
Disease: Benign neoplasm of stomach
Benign neoplasm of stomach 		0.300 CausalMutation disease CGI
CUI: C0154060
Disease: Carcinoma in situ of stomach
Carcinoma in situ of stomach 		0.300 CausalMutation disease CGI
CUI: C0496905
Disease: Neoplasm of uncertain or unknown behavior of stomach
Neoplasm of uncertain or unknown behavior of stomach 		0.300 CausalMutation disease CGI
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.300 Biomarker disease CTD_human
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.120 CausalMutation disease CLINVAR
CUI: C0007120
Disease: Bronchioloalveolar Adenocarcinoma
Bronchioloalveolar Adenocarcinoma 		0.100 Biomarker disease HPO
CUI: C0544886
Disease: Somatic mutation
Somatic mutation 		0.100 Biomarker phenotype HPO
CUI: C4703633
Disease: Increased level of L-fucose in urine
Increased level of L-fucose in urine 		0.100 Biomarker phenotype HPO
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.030 Biomarker disease BEFREE <b>Methods</b>: We induced experimental atherosclerosis in ApoE<sup>-/-</sup>IRF1<sup>-/-</sup> mice and evaluated the effect of IRF1 on disease progression and foam cell formation. 31367250 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.030 Biomarker disease BEFREE <b>Methods</b>: We induced experimental atherosclerosis in ApoE<sup>-/-</sup>IRF1<sup>-/-</sup> mice and evaluated the effect of IRF1 on disease progression and foam cell formation. 31367250 2019
CUI: C0375023
Disease: Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site 		0.020 AlteredExpression disease BEFREE RSV enhanced IRF-1 and iNOS mRNA expression as early as 4 h after RSV infection and this enhancement lasted several hours. 10410996 1999
CUI: C3463824
Disease: MYELODYSPLASTIC SYNDROME
MYELODYSPLASTIC SYNDROME 		0.100 AlteredExpression group BEFREE Myelodysplastic syndrome (MDS) patients with an absence of full-length IRF-1 mRNA also overexpressed Annexin-II. 18084608 2007
CUI: C3539878
Disease: Triple Negative Breast Neoplasms
Triple Negative Breast Neoplasms 		0.020 AlteredExpression disease BEFREE Triple negative breast cancer subtype was associated with higher expression of IRF1, FOXC1 and MKI67. 22489698 2012