IRF1, interferon regulatory factor 1, 3659

N. diseases: 257; N. variants: 7
Disease: leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023418
Disease: leukemia
leukemia 		0.060 GeneticVariation disease BEFREE The interferon regulatory factor 1 (IRF-1) gene is located at 5q31, the site of common deletions in myelodysplastic syndromes (MDS) and secondary leukemias. 10807049 2000
CUI: C0023418
Disease: leukemia
leukemia 		0.060 Biomarker disease BEFREE The loss of functional IRF-1 has been observed in a number of patients with myelodysplastic syndrome (MDS) and leukemia, suggesting a potentially critical role of IRF-1 in leukemogenesis. 10609788 1999
CUI: C0023418
Disease: leukemia
leukemia 		0.060 Biomarker disease BEFREE The loss of functional IRF-1 has been observed in a significant number of patients with myelodysplastic syndrome (MDS) and leukemia, suggesting a potentially critical role of IRF-1 in human oncostasis. 9315094 1997
CUI: C0023418
Disease: leukemia
leukemia 		0.060 GeneticVariation disease BEFREE This result predicts diminished expression of PKR as a potential consequence of deletion of the IRF-1 gene in human leukemias. 8622878 1996
CUI: C0023418
Disease: leukemia
leukemia 		0.060 AlteredExpression disease BEFREE Accelerated exon skipping of IRF-1 mRNA in human myelodysplasia/leukemia; a possible mechanism of tumor suppressor inactivation. 7936656 1994
CUI: C0023418
Disease: leukemia
leukemia 		0.060 Biomarker disease BEFREE Thus, IRF-1 may be a critically deleted gene in human leukemia and myelodysplasia. 8438156 1993