IRF1, interferon regulatory factor 1, 3659

N. diseases: 257; N. variants: 7
Disease: Carcinogenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.080 Biomarker phenotype BEFREE Here, we report that XAF1 forms a positive feedback loop with interferon regulatory factor-1 (IRF-1) and functions as a transcriptional coactivator of IRF-1 to suppress tumorigenesis. 30042418 2018
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.080 GeneticVariation phenotype BEFREE Deletions, mutations or aberrant splicing of IRF-1 would result in its functional inactivation, and closely related to the tumorigenesis. 28039033 2017
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.080 AlteredExpression phenotype BEFREE In this study, we sought to determine whether IRF1 downregulation underlies oncogenesis induced by Ras/MEK activation in human cancer cells. 25497010 2015
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.080 Biomarker phenotype BEFREE To demonstrate the role of SUMOylated IRF-1 in tumorigenesis, we used SUMO-IRF-1 recombinant protein. 19962964 2010
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.080 Biomarker phenotype BEFREE IRF-1 promotes apoptosis in p53-damaged basal-type human mammary epithelial cells: a model for early basal-type mammary carcinogenesis. 18497060 2008
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.080 Biomarker phenotype BEFREE The specific combinations of p53, p21, and IRF-1 gene-gene and gene-environmental interactions were significantly noted in the cervix carcinogenesis of Korean women. 14764039 2004
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.080 Biomarker phenotype BEFREE Defects in IRF-1 occur frequently in human cancers and may contribute to tumorigenesis. 10395927 1999
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.080 AlteredExpression phenotype BEFREE Regulation of the interferon system, immune response and oncogenesis by the transcription factor interferon regulatory factor-1. 9831185 1998