The constructed rats models of MI were randomly divided into 6 groups: control group (sham operation group, MI modeling sham operation), model group (MI modeling), NC group (MI modeling, tail vein injection of AQP9 negative control sequence vector), AQP9 shRNA group (MI modeling, tail vein injection of AQP9 shRNA plasmid vector), U0126 group (MI modeling, tail vein injection of ERK signaling pathway inhibitor), and AQP9 shRNA + U0126 group.
The genes <i>TFEB</i>,<i>IRS2</i>,<i>GRB2</i>,<i>FASLG</i>,<i>LIMS1</i>,<i>CX3CR1</i>,<i>HSPA6</i>,<i>TPM3</i>,<i>LAT2</i>,<i>CEBPD</i>,<i>AQP9,</i> and <i>MAPKAPK2</i> were associated with recovery from MI.