IRF2, interferon regulatory factor 2, 3660

N. diseases: 86; N. variants: 9
Disease: Esophageal carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma 		0.020 AlteredExpression disease BEFREE Then, over-expressed of miR-302b significantly altered potential target genes protein expressions and there was a negative correlation between miR-302b and potential target genes protein expressions (ERBB4, IRF2 and CXCR4) in EC tissues. 28467773 2017
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma 		0.020 Biomarker disease BEFREE Taken together, our results disclosed a new IRF-2-mediated inhibitory mechanism for IFN-gamma-induced pathway in esophageal cancer cells: IFN-gamma induced IRF-2 up-regulation, then up-regulated IRF-2 decreased endogenous IFNGR1 level, and finally, the loss of IFNGR1 turned to enhance the resistance of esophageal cancer cells to IFN-gamma. 18281489 2008