IRF3, interferon regulatory factor 3, 3661

N. diseases: 174; N. variants: 9
Disease: Herpes encephalitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0276226
Disease: Herpes encephalitis
Herpes encephalitis 		0.330 Biomarker disease BEFREE These diseases encompass herpes simplex encephalitis (HSE) and severe influenza in IRF3- and IRF7/IRF9 deficiency, respectively. 30671054 2018
CUI: C0276226
Disease: Herpes encephalitis
Herpes encephalitis 		0.330 Biomarker disease BEFREE The identification of IRF3 deficiency in HSE provides the first description of a defect in an IFN-regulating transcription factor conferring increased susceptibility to a viral infection in the CNS in humans. 26216125 2015
CUI: C0276226
Disease: Herpes encephalitis
Herpes encephalitis 		0.330 GeneticVariation disease BEFREE We identified novel mutations in IRF3, TYK2 and MAVS, molecules involved in generating innate antiviral immune responses, which have not previously been associated with HSE. 26513235 2015
CUI: C0276226
Disease: Herpes encephalitis
Herpes encephalitis 		0.330 Biomarker disease CTD_human