IRF4, interferon regulatory factor 4, 3662

N. diseases: 203; N. variants: 10
Disease: Kaposi Sarcoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma 		0.050 Biomarker disease BEFREE Primary effusion lymphoma (PEL), strongly linked with latent infection of Kaposi's sarcoma-associated herpesvirus (KSHV), constitutively expresses cellular interferon regulatory factor 4 (IRF4) while suppressing the expression of B cell lymphoma 6 (BCL6). 29397940 2018
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma 		0.050 Biomarker disease BEFREE Moreover, Kaposi sarcoma-associated herpesvirus (KSHV)-encoded viral FLICE inhibitory protein (vFLIP) enhances IRF4-mediated gene induction. 23804715 2013
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma 		0.050 Biomarker disease BEFREE Cooperation between viral interferon regulatory factor 4 and RTA to activate a subset of Kaposi's sarcoma-associated herpesvirus lytic promoters. 22090118 2012
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma 		0.050 AlteredExpression disease BEFREE These plasmablasts were positive for MUM1 and vIL6, co-expressed EBV and LNA-1 of HHV-8/KSHV, and showed a polyclonal pattern of Ig gene rearrangements on PCR. 21509436 2011
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma 		0.050 Biomarker disease BEFREE Finally, MUM1/IRF4 may interact with HHV-8/KSHV-encoded interferon regulatory factors (IRFs) and thus contribute to PEL escape from interferon-mediated control of viral infection. 11091208 2000