IRF5, interferon regulatory factor 5, 3663

N. diseases: 226; N. variants: 15
Disease: Arteriosclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.020 Biomarker disease BEFREE A significant loss of CD11c<sup>+</sup> macrophages was evident in ApoE<sup>-/-</sup>Irf5<sup>-/-</sup> mice in the aorta, draining lymph nodes, and bone marrow cell cultures, indicating that IRF5 maintains CD11c<sup>+</sup> macrophages in atherosclerosis. 28698173 2017
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.020 Biomarker disease BEFREE Recently, IRF-5 has been implicated in inflammatory processes that are associated with excessive remodeling and atherosclerosis. 19778284 2010