IRF5, interferon regulatory factor 5, 3663

N. diseases: 226; N. variants: 15
Disease: Obesity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.030 AlteredExpression disease BEFREE In conclusion, elevated adipose IRF5 expression in obesity concurs with the typical inflammatory signatures, locally and systemically. 31718015 2019
CUI: C0028754
Disease: Obesity
Obesity 		0.030 Biomarker disease BEFREE This study demonstrates that cytosolic Pellino-1-mediated K63-linked ubiquitination of IRF5 in M1 macrophages regulates glucose intolerance in obesity, suggesting a cytosolic mediator function of Pellino-1 in TLR4/IFN-γ receptor-IRF5 axis during M1 polarization. 28746869 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.030 Biomarker disease BEFREE This study uncovers a new function for IRF5 in controlling the relative mass of different adipose tissue depots and thus insulin sensitivity in obesity, and it suggests that inhibition of IRF5 may promote a healthy metabolic state during this condition. 25939064 2015