IRF5, interferon regulatory factor 5, 3663

N. diseases: 226; N. variants: 15
Disease: Virus Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.100 Biomarker group BEFREE Black carp IRF5 interacts with TBK1 to trigger cell death following viral infection. 31260698 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.100 Biomarker group BEFREE Using integrative bioinformatics analyses, we identified new IRF5 primary target genes in DCs in response to virus infection. 30457675 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.100 AlteredExpression group BEFREE Furthermore, the levels of IRF5 and IFN-a increased significantly in the early phase of pneumonia caused by influenza virus infection. 29847542 2018
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.100 AlteredExpression group BEFREE Interferon regulatory factor-5 (IRF-5), a member of the mammalian IRF transcription factor family, is regulated by p53, type I interferon and virus infection. 25557482 2015
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.100 AlteredExpression group BEFREE Interferon Regulatory Factor 5 is a transcription factor that regulates the expression of genes involved in the response to viral infection and in the stimulation of the immune system. 22507190 2012
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.100 Biomarker group BEFREE The transcription factor Interferon Regulatory Factor 5 (IRF-5) has been shown to be involved in the induction of proinflammatory cytokines in response to viral infections and TLR activation and to play an essential role in the innate inflammatory response. 21253574 2011
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.100 Biomarker group BEFREE In recent reports, IRF5 polymorphisms showed significant association with multiple sclerosis (MS) susceptibility in three studied populations and Irf5-deficient mice exhibited an increased susceptibility to viral infection, linked to a significant decrease in the induction of serum type I interferon (IFN). 20861862 2011
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.100 Biomarker group BEFREE Lung cancer cells can be partially protected from viral killing using IRF5+IRF7 overexpression, whereas IFN pathway disruption by transfection of siRNAs to IRF5+IRF7 increases cells' vulnerability to viral infection. 22194884 2011
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.100 Biomarker group BEFREE Interferon regulatory factor 5 (IRF5) regulates innate immune responses to viral infection. 20695768 2011
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.100 Biomarker group BEFREE When compared with C57BL/6 mice, Irf5(-/-) mice show higher susceptibility to viral infection and decreased serum levels of type I IFN and the inflammatory cytokines IL-6 and TNF-alpha. 20176957 2010
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.100 AlteredExpression group BEFREE Patients carrying the 4R CGGGG IRF5 allele had a high level of mRNA for IRF5 in PBMCs and salivary gland epithelial cells, mainly after in vitro viral infection. 19565491 2009
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.100 AlteredExpression group BEFREE Along with IRF3 and IRF7, NSP1 was found to induce the degradation of IRF5, a factor that upregulates IFN expression and that is involved in triggering apoptosis during viral infection. 17301153 2007
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.100 Biomarker group BEFREE We have previously shown a critical role for IFN regulatory factor 5 (IRF-5) in the innate immune response to virus infection. 14559832 2003