Lupus Erythematosus, Systemic
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Transancestral mapping and genetic load in systemic lupus erythematosus.
|
28714469 |
2017 |
Lupus Erythematosus, Systemic
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, inhibition of Pin1 using either validated Pin1 shRNA or ATRA blocked TLR-7-induced activation of IRAK-1 and IRF-7 in SLE patient-derived immune cells.
|
27159270 |
2016 |
Lupus Erythematosus, Systemic
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.
|
27399966 |
2016 |
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
The type-I interferon master regulator gene IRF7 is only hypomethylated in lupus patients with renal involvement.
|
26005050 |
2015 |
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
IRF7, a functional factor associates with systemic lupus erythematosus.
|
22455868 |
2012 |
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
These results confirmed recently reported association of PHRF1 rs4963128T with anti-Sm antibody positive SLE in African-American populations, and supported the role of PHRF1-IRF7 region in the genetics of SLE.
|
22433914 |
2012 |
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
Recent studies have reported an association between IRF7 and SLE which confers a risk to autoantibody production.
|
21926187 |
2012 |
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
This result provides direct genetic evidence that IRF7 may be a risk gene for human SLE.
|
21360504 |
2011 |
Lupus Erythematosus, Systemic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We decided to investigate the association of single-nucleotide polymorphisms (SNPs) in the IRF7/KIAA1542 region (rs4963128, rs2246614, and rs702966) and in STAT4 (rs7574865 and rs7582694) with SLE disease in a Northern Han Chinese population of 748 patients and 750 healthy controls.
|
21167895 |
2011 |
Lupus Erythematosus, Systemic
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Western blot analysis showed that induction of IRF7 protein expression correlated with recurrent lupus disease activity.
|
21576205 |
2011 |
Lupus Erythematosus, Systemic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in the IRF5 and IRF7 genes have been associated with SLE susceptibility, and these same variants are associated with increased serum IFN-α in SLE patients.
|
21575916 |
2011 |
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
Specific emphasis will be made over the role of IRF-5 and IRF-7, since evidence of its association to the development of pathology, particularly systemic lupus erythematosus is the strongest.
|
21872684 |
2011 |
Lupus Erythematosus, Systemic
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Compared with controls, the expression of IRF7 mRNA was significantly increased in patients with SLE and was positively correlated with both the serum level of IFN-α and lupus disease activity.
|
21632682 |
2011 |
Lupus Erythematosus, Systemic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study was undertaken to determine whether variants of IRF7 act as risk factors for SLE by increasing IFNalpha production and whether autoantibodies are important to this phenomenon.
|
20112359 |
2010 |