IRF7, interferon regulatory factor 7, 3665

N. diseases: 121; N. variants: 11
Disease: Lupus Erythematosus, Systemic ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1131665
rs1131665
Entrez Id: 3665
Gene Symbol: IRF7
IRF7
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic 		0.720 GeneticVariation GWASCAT Transancestral mapping and genetic load in systemic lupus erythematosus. 28714469 2017
dbSNP: rs1131665
rs1131665
Entrez Id: 3665
Gene Symbol: IRF7
IRF7
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic 		0.720 GeneticVariation BEFREE Although recent studies detected association of a single nucleotide polymorphism (SNP) rs4963128 in PHD and ring finger domains 1 (PHRF1)/KIAA1542, located closely to IRF7, and IRF7 rs1131665 (glutamine (Gln) 412 arginine (Arg)) with systemic lupus erythematosus (SLE), causal variants have not been established. 22433914 2012
dbSNP: rs1131665
rs1131665
Entrez Id: 3665
Gene Symbol: IRF7
IRF7
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic 		0.720 GeneticVariation BEFREE These findings show that the major allele of a nonsynonymous SNP, rs1131665 (412Q) in IRF7, confers elevated activation of IRF-7 and predisposes to the development of SLE in multiple ethnic groups. 21360504 2011
dbSNP: rs112006329
rs112006329
Entrez Id: 3665;53841
Gene Symbol: IRF7;CDHR5
IRF7;CDHR5
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic 		0.700 GeneticVariation GWASCAT Transancestral mapping and genetic load in systemic lupus erythematosus. 28714469 2017
dbSNP: rs1061502
rs1061502
Entrez Id: 3665
Gene Symbol: IRF7
IRF7
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic 		0.700 GeneticVariation GWASCAT Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus. 27399966 2016
dbSNP: rs1061501
rs1061501
Entrez Id: 3665
Gene Symbol: IRF7
IRF7
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic 		0.010 GeneticVariation BEFREE The IRF7 SNP rs1061501 TT genotype and T allele are enriched in Taiwanese patients with SLE and thus would seem to be associated with an increased risk of developing SLE. 21632682 2011