IRF7, interferon regulatory factor 7, 3665

N. diseases: 121; N. variants: 11
Disease: Lyme Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024198
Disease: Lyme Disease
Lyme Disease 		0.010 Biomarker disease BEFREE Phagocytosed Borrelia burgdorferi (Bb), the Lyme disease spirochete, induces a robust and complex innate immune response in human monocytes, in which TLR8 cooperates with TLR2 in the induction of NF-κB-mediated cytokine production, whereas TLR8 is solely responsible for transcription of IFN-β through IRF7. 23906644 2013