IRF7, interferon regulatory factor 7, 3665

N. diseases: 121; N. variants: 11
Disease: General Paralysis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0205858
Disease: General Paralysis
General Paralysis 		0.010 Biomarker disease BEFREE IRF7-/- mice died 5-8 days after infection with rapidly progressive paralysis and differed from both WT and IRF3-/- mice in the induction of higher CNS levels of IFNβ, tumour necrosis factor (TNF) α and Cxcl13 mRNA, delayed virus clearance and more extensive cell death. 30451651 2019