|
Gestational Diabetes
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Adipose tissue mRNA expression analyses of insulin signalling genes: <i>PI3KCA, PI3KR1, IRS1 and IRS2</i> showed significantly decreased <i>PI3KR1</i> expression (-23%) in visceral fat in GDM with no association to promoter DNA methylation.
|
31608772 |
2019 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The rs13266634/T (SLC30A8, OR = 0.74/0.71, p = 0.05/0.02) and rs7578326/G (LOC646736/IRS1, OR = 0.62/0.60, p = 0.001/0.006) variants were associated with lower risk to develop GDM.
|
28072873 |
2017 |
|
Gestational Diabetes
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In addition, more severe IR was observed in the placenta of GDM patients than the control group, evidenced with higher pIRS-1(ser312) (p<0.001) and lower IRS-1 (p<0.05) as well as pAkt proteins (p<0.01).
|
27340831 |
2016 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The OGTT test using 100 g, but not 75 g; and genotype detection by other assays, but not Taqman method, were also significantly associated with increased GDM risk in rs1801278(IRS1) and rs7903146(TCF7L2).
|
27468700 |
2016 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In conclusion, our study found that the genetic polymorphisms rs10830963 and rs1387153 in MTNR1B and rs1801278 in IRS1 were associated with an increased risk of developing GDM.
|
25146448 |
2014 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The aim of the present study was to scrutinize the relationship between the G972R polymorphism of the insulin receptor substrate-1 (IRS-1) gene with GDM in the Saudi female population.
|
24695443 |
2014 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (rs5219" genes_norm="3767">E23K, KCNJ11), rs7754840 (CDKAL1), rs4402960 (IGF2BP2), rs10830963 (MTNR1B), rs1387153 (MTNR1B) and rs1801278 (rs1801278" genes_norm="3667">Gly972Arg, IRS1) were significantly associated with a higher risk of GDM.
|
23690305 |
2013 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2 (rs7903146 C/T) gene, and the G972R polymorphism of the IRS1 gene, seem to predispose to GDM in Greek women.
|
20540670 |
2011 |
|
Gestational Diabetes
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Both adipose tissue and skeletal muscle from women with GDM displayed decreased IRS-1 and GLUT-4 and increased PI3-K p85alpha protein expression.
|
19955252 |
2010 |
|
Gestational Diabetes
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
There was a significant increase in insulin receptor (IR) substrate (IRS)-1 protein expression with a concurrent decrease in IRS-2 protein expression in non-obese women with insulin-controlled GDM compared with diet-controlled GDM and normal controls.
|
19179458 |
2009 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The X-Arg genotype of IRS-1 was significantly associated with a positive family history of diabetes in NGT (P = .006) and neared significance in GDM (P = .057).
|
17046546 |
2006 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
IRS-1 G972R was associated with the baseline characteristics of the patients with GDM, and might be related to insulin resistance that is seen in obese patients with GDM.
|
16522427 |
2006 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Analysis of the IRS1 G972R polymorphism showed that RR homozygosity was found exclusively in women with GDM (91.0, 8.3 and 0.7% vs 90.7, 9.3 and 0.0% for GG, GR and RR genotypes, respectively; p=0.014).
|
16320083 |
2005 |
|
Gestational Diabetes
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Downregulated IRS-1 and PPARgamma in obese women with gestational diabetes: relationship to FFA during pregnancy.
|
11832353 |
2002 |