IRS1, insulin receptor substrate 1, 3667

N. diseases: 233; N. variants: 15
Disease: Hyperandrogenism ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0206081
Disease: Hyperandrogenism
Hyperandrogenism 		0.030 Biomarker disease LHGDN Selective alterations in insulin receptor substrates-1, -2 and -4 in theca but not granulosa cells from polycystic ovaries. 15155816 2004
CUI: C0206081
Disease: Hyperandrogenism
Hyperandrogenism 		0.030 GeneticVariation disease BEFREE Serum androgen, IGFBP-1, and SHBG concentrations; IRS-1 genotypes.Twenty-five of 54 (45%) girls with a history of PP developed hyperinsulinemic ovarian hyperandrogenism at adolescence. 12477526 2002
CUI: C0206081
Disease: Hyperandrogenism
Hyperandrogenism 		0.030 Biomarker disease BEFREE Among the HA, 5 of 58 (8.6%), 3 of 58 (5%), and 6 of 58 (10%) alleles showed the IRS-1, GRL, and ADRB3 variants, respectively. 11287026 2001