IRS1, insulin receptor substrate 1, 3667

N. diseases: 233; N. variants: 15
Disease: Precocious pubarche ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0342541
Disease: Precocious pubarche
Precocious pubarche 		0.020 GeneticVariation disease BEFREE Serum androgen, IGFBP-1, and SHBG concentrations; IRS-1 genotypes.Twenty-five of 54 (45%) girls with a history of PP developed hyperinsulinemic ovarian hyperandrogenism at adolescence. 12477526 2002
CUI: C0342541
Disease: Precocious pubarche
Precocious pubarche 		0.020 Biomarker disease BEFREE Among the PP, 11 of 80 (14%), 5 of 80 (6%), and 7 of 80 (9%) alleles showed the IRS-1, GRL, and ADRB3 variants, respectively. 11287026 2001