IRS1, insulin receptor substrate 1, 3667

N. diseases: 233; N. variants: 15
Disease: Insulin resistance syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3714619
Disease: Insulin resistance syndrome
Insulin resistance syndrome 		0.020 GeneticVariation disease BEFREE The most common IRS1 variant, a Gly --> Arg substitution at codon 972 (Arg972 IRS1), is more prevalent among subjects who have features of insulin resistance syndrome associated, or not, with type 2 diabetes in European populations. 15222685 2004
CUI: C3714619
Disease: Insulin resistance syndrome
Insulin resistance syndrome 		0.020 Biomarker disease BEFREE Carriers of Arg(972) IRS-1 displayed many features of the insulin resistance syndrome, including higher values for serum triglycerides (P < 0.01), total/high density lipoprotein cholesterol ratio (P < 0.01), free fatty acid levels (P < 0.04), systolic blood pressure (P < 0.04), microalbuminuria (P < 0.003), and intima-media thickness (P < 0.02). 12843189 2003