Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Malignant neoplasm of prostate
|
1.000 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
Malignant neoplasm of prostate
|
1.000 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Malignant neoplasm of prostate
|
1.000 |
Biomarker
|
disease |
HPO |
|
|
|
Malignant neoplasm of prostate
|
1.000 |
Biomarker
|
disease |
BEFREE |
(2) The c-erb B-2/neu protein was detected in both androgen-receptor-positive (LNCaP) and -negative (PC-3 and DU-145) human prostate cancer cell lines.
|
1353965 |
1992 |
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Androgen receptor gene mutations in human prostate cancer.
|
1631125 |
1992 |
Malignant neoplasm of prostate
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
Increased androgen receptor activity and altered c-myc expression in prostate cancer cells after long-term androgen deprivation.
|
7511045 |
1994 |
Malignant neoplasm of prostate
|
1.000 |
Biomarker
|
disease |
BEFREE |
Androgen receptor status in localized and locally progressive hormone refractory human prostate cancer.
|
7512791 |
1994 |
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Androgen receptor gene mutations in prostate cancer are very rare and are reported only in exons 4-8.
|
7626493 |
1995 |
Malignant neoplasm of prostate
|
1.000 |
Biomarker
|
disease |
BEFREE |
We analyzed the androgen-receptor genes from samples of metastatic androgen-independent prostate cancers to determine whether mutations in the gene have a role in androgen independence.
|
7723794 |
1995 |
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The CAG and GGC microsatellites of the androgen receptor gene are in linkage disequilibrium in men with prostate cancer.
|
7728763 |
1995 |
Malignant neoplasm of prostate
|
1.000 |
Biomarker
|
disease |
BEFREE |
We have identified a similar molecular mechanism in vivo for endocrine treatment failure in human prostate cancer which involves amplification of the androgen receptor (AR) gene.
|
7795646 |
1995 |
Malignant neoplasm of prostate
|
1.000 |
Biomarker
|
disease |
BEFREE |
Evidence coming from studies on AR in prostatic cancer highlights the possibility that AR structural alterations may have significance in tumor progression.
|
7971517 |
1994 |
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
It is possible that analogous to an activated/altered growth factor receptor oncogene, codon 877 mutant AR with altered ligand binding may provide a selective growth advantage in the genesis of a subset of advanced prostate cancer.
|
8187068 |
1994 |
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Androgen receptor gene mutations in human prostate cancer.
|
8274409 |
1993 |
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Microsatellite mutation (CAG24-->18) in the androgen receptor gene in human prostate cancer.
|
8292051 |
1994 |
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that androgen receptor mutations are probably uncommon molecular events in the early stages of prostatic cancer.
|
8426836 |
1993 |
Malignant neoplasm of prostate
|
1.000 |
Biomarker
|
disease |
BEFREE |
Androgen-induced inhibition of cell proliferation in an androgen-insensitive prostate cancer cell line (PC-3) transfected with a human androgen receptor complementary DNA.
|
8443809 |
1993 |
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Mutated human androgen receptor gene detected in a prostatic cancer patient is also activated by estradiol.
|
8530589 |
1995 |
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
It could be speculated that this specific mutant androgen receptor provides a selective growth advantage in a subset of advanced prostate cancers.
|
8717468 |
1996 |
Malignant neoplasm of prostate
|
1.000 |
Biomarker
|
disease |
BEFREE |
To further investigate structural abnormality of the AR in a large number of human prostate cancers, exons B-H encoding DNA-and hormone-binding domains were examined by single-strand conformation polymorphism analysis of polymerase chain reaction products and direct sequencing.
|
8827083 |
1996 |
Malignant neoplasm of prostate
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
Here we shown that androgen promoted up-regulation of AR mRNA in two androgen-independent human prostate cancer cell lines, PC3 and DU145, when each was transfected with a human AR cDNA.
|
8883219 |
1996 |
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Some AR mutations in prostate cancer show broadened ligand specificity, such that the transcription-factor activity of the AR can be stimulated not just by dihydrotestosterone (DHT) but also by estradiol and other androgen metabolites that have a low affinity for the AR.
|
8912473 |
1996 |
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Fifty-seven non-Hispanic white case patients with prostate cancer and 169 non-Hispanic white control subjects were genotyped for a previously described microsatellite (CAG repeats) in the AR gene and for a newly discovered poly-A microsatellite in the 3'-untranslated region (3'UTR) of the VDR gene.
|
8998186 |
1997 |