|
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Malignant neoplasm of prostate
|
1.000 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Malignant neoplasm of prostate
|
1.000 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Malignant neoplasm of prostate
|
1.000 |
Biomarker
|
disease |
HPO |
|
|
|
|
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Androgen receptor gene mutations in human prostate cancer.
|
1631125 |
1992 |
|
Malignant neoplasm of prostate
|
1.000 |
Biomarker
|
disease |
BEFREE |
(2) The c-erb B-2/neu protein was detected in both androgen-receptor-positive (LNCaP) and -negative (PC-3 and DU-145) human prostate cancer cell lines.
|
1353965 |
1992 |
|
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that androgen receptor mutations are probably uncommon molecular events in the early stages of prostatic cancer.
|
8426836 |
1993 |
|
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Androgen receptor gene mutations in human prostate cancer.
|
8274409 |
1993 |
|
Malignant neoplasm of prostate
|
1.000 |
Biomarker
|
disease |
BEFREE |
Androgen-induced inhibition of cell proliferation in an androgen-insensitive prostate cancer cell line (PC-3) transfected with a human androgen receptor complementary DNA.
|
8443809 |
1993 |
|
Malignant neoplasm of prostate
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
Increased androgen receptor activity and altered c-myc expression in prostate cancer cells after long-term androgen deprivation.
|
7511045 |
1994 |
|
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Microsatellite mutation (CAG24-->18) in the androgen receptor gene in human prostate cancer.
|
8292051 |
1994 |
|
Malignant neoplasm of prostate
|
1.000 |
Biomarker
|
disease |
BEFREE |
Evidence coming from studies on AR in prostatic cancer highlights the possibility that AR structural alterations may have significance in tumor progression.
|
7971517 |
1994 |
|
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
It is possible that analogous to an activated/altered growth factor receptor oncogene, codon 877 mutant AR with altered ligand binding may provide a selective growth advantage in the genesis of a subset of advanced prostate cancer.
|
8187068 |
1994 |
|
Malignant neoplasm of prostate
|
1.000 |
Biomarker
|
disease |
BEFREE |
Androgen receptor status in localized and locally progressive hormone refractory human prostate cancer.
|
7512791 |
1994 |
|
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The CAG and GGC microsatellites of the androgen receptor gene are in linkage disequilibrium in men with prostate cancer.
|
7728763 |
1995 |
|
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Androgen receptor gene mutations in prostate cancer are very rare and are reported only in exons 4-8.
|
7626493 |
1995 |
|
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Mutated human androgen receptor gene detected in a prostatic cancer patient is also activated by estradiol.
|
8530589 |
1995 |
|
Malignant neoplasm of prostate
|
1.000 |
Biomarker
|
disease |
BEFREE |
We analyzed the androgen-receptor genes from samples of metastatic androgen-independent prostate cancers to determine whether mutations in the gene have a role in androgen independence.
|
7723794 |
1995 |
|
Malignant neoplasm of prostate
|
1.000 |
Biomarker
|
disease |
BEFREE |
We have identified a similar molecular mechanism in vivo for endocrine treatment failure in human prostate cancer which involves amplification of the androgen receptor (AR) gene.
|
7795646 |
1995 |
|
Malignant neoplasm of prostate
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
In other cases, altered androgen receptor activity due to its mutation or altered expression may lead to pathology such as recurrence of prostate cancer due to development of androgen independence allowing tumor cell proliferation under androgen deprivation.
|
9159212 |
1996 |
|
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
These data indicate that AR gene mutations occur commonly in advanced prostate cancers prior to endocrine treatment of disease and may contribute to altered androgen responsiveness of the tumors.
|
9816170 |
1996 |
|
Malignant neoplasm of prostate
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
Here we shown that androgen promoted up-regulation of AR mRNA in two androgen-independent human prostate cancer cell lines, PC3 and DU145, when each was transfected with a human AR cDNA.
|
8883219 |
1996 |
|
Malignant neoplasm of prostate
|
1.000 |
Biomarker
|
disease |
BEFREE |
To further investigate structural abnormality of the AR in a large number of human prostate cancers, exons B-H encoding DNA-and hormone-binding domains were examined by single-strand conformation polymorphism analysis of polymerase chain reaction products and direct sequencing.
|
8827083 |
1996 |
|
Malignant neoplasm of prostate
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
It could be speculated that this specific mutant androgen receptor provides a selective growth advantage in a subset of advanced prostate cancers.
|
8717468 |
1996 |