|
Malignant neoplasm of endometrium
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genome-wide AR analysis in PCOS stromal cells revealed that AR targets included genes involved in cell death and apoptosis, as well as genes commonly dysregulated in endometrial cancer.
|
31256208 |
2019 |
|
Malignant neoplasm of endometrium
|
0.100 |
Biomarker
|
disease |
BEFREE |
This report examined the interplay between AR-Qs and BaP in EMCA.
|
28782227 |
2018 |
|
Malignant neoplasm of endometrium
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of estrogen receptor, progesterone receptor (PgR), androgen receptor, and Ki67 index was assessed with residual tissue samples of endometrial cancer.
|
28540420 |
2017 |
|
Malignant neoplasm of endometrium
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review proved strong correlation among EC, AngII, its receptors and AR, where AT influence on AR and, as a result, induce the expression of genes related to carcinogenesis.
|
25231075 |
2015 |
|
Malignant neoplasm of endometrium
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Together, these findings demonstrate that KDM4B and KDM4A promote EC progression by regulating AR activity.
|
26397136 |
2015 |
|
Malignant neoplasm of endometrium
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In our case-control study, the strongest association with endometrial cancer risk was for AR (androgen receptor; ARTP P = 0.006).
|
20053928 |
2010 |
|
Malignant neoplasm of endometrium
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Only one of these studies measured haplotype-tagging single nucleotide polymorphisms (htSNP) in AR and found statistically nonsignificant, decreased associations with endometrial cancer risk.
|
19190146 |
2009 |
|
Malignant neoplasm of endometrium
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Associations for the AR CAG average repeat length and endometrial cancer risk differed by menopausal status (p = 0.02).
|
16161040 |
2006 |
|
Malignant neoplasm of endometrium
|
0.100 |
Biomarker
|
disease |
BEFREE |
The endometrium contains ARs and the androgens have antiproliferative properties in cultured endometrial cancer (EC) cells.
|
16187285 |
2006 |
|
Malignant neoplasm of endometrium
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, we investigated whether these AR polymorphisms are risk factors for endometrial cancer.
|
15721279 |
2005 |
|
Malignant neoplasm of endometrium
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also investigated whether the expression of estrogen receptors (ERalpha and ERbeta), progesterone receptor, and androgen receptor genes are influenced by the CYP1B1 genotypes in endometrial cancer.
|
12873984 |
2003 |
|
Malignant neoplasm of endometrium
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We hypothesize that the length of CAG repeats on the AR gene can predict higher incidence of endometrial cancer.
|
12767946 |
2003 |
|
Malignant neoplasm of endometrium
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that DHT may play more important roles than testosterone in the regulation of androgen action in endometrial cancer and normal human endometrium, especially in the secretory phase, in which both AR and 5alpha-reductase are increased.
|
12115497 |
2002 |
|
Malignant neoplasm of endometrium
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
This study is the first to report that the possible mechanism of AR inactivation in endometrial cancer is through hypermethylation of the AR gene CpG islands.
|
11074602 |
2000 |