|
Androgenetic Alopecia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
DHT binds to the androgen receptor (AR) in scalp dermal papilla cells (DPC) to induce AR-mediated transcription of genes that contribute to AGA in genetically predisposed individuals.
|
30811143 |
2019 |
|
Androgenetic Alopecia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Comparative full transcriptome profile analysis of the hair bulb region of normal and miniaturized hair follicles from vertex and occipital region in males with and without androgenetic alopecia revealed that next to the androgen receptor as well the retinoid receptor and particularly the PPAR pathway is involved in progressive hair miniaturization.
|
31217429 |
2019 |
|
Androgenetic Alopecia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we analyze recent studies of androgens and AR roles in several skin-related disorders, focusing in the current understanding of their molecular mechanisms in androgenetic alopecia (AGA).
|
28912032 |
2018 |
|
Androgenetic Alopecia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This review describes recent studies on the role of androgens and androgen receptor (AR) transactivation activity in modulating the Wnt/β-catenin signaling in the dermal papilla cells of the balding scalp in androgenetic alopecia.
|
29549490 |
2018 |
|
Androgenetic Alopecia
|
0.400 |
Biomarker
|
disease |
BEFREE |
To date, the strongest predictor of AGA in men has been the length of the CAG repeat located in the androgen receptor gene (AR gene) on the X chromosome.
|
29254307 |
2018 |
|
Androgenetic Alopecia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several studies indicate that the numbers of CAG/GGC repeats in exon 1 of the androgen receptor gene (AR) maybe associated with AGA susceptibility.
|
26178169 |
2015 |
|
Androgenetic Alopecia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We confirmed that the AR gene polymorphism (SNP rs6152 G>A) is associated with the development of AGA and higher PSA levels in patients with BPH but not cancer.
|
24665929 |
2015 |
|
Androgenetic Alopecia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our recent findings indicate that the major AGA locus, an X-chromosome region containing the androgen receptor and the ectodysplasin A2 receptor (EDA2R) genes, may represent a common genetic factor underlying both early-onset FPHL and AGA.
|
24352509 |
2014 |
|
Androgenetic Alopecia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A negative correlation was identified between AR expression and the number of CAG repeats only in AGA patients (r = 0.510; P = 0.013).
|
23479164 |
2013 |
|
Androgenetic Alopecia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results define androgen/androgen receptor signaling as an accelerator of premature senescence in dermal papilla cells and suggest that the androgen/androgen receptor-mediated DNA damage-p16(INK4a) axis is a potential therapeutic target in the treatment of androgenetic alopecia.
|
24244503 |
2013 |
|
Androgenetic Alopecia
|
0.400 |
Biomarker
|
disease |
BEFREE |
It is known that baldness caused by androgenetic alopecia is involved with androgen and the androgen receptor.
|
23955654 |
2013 |
|
Androgenetic Alopecia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Androgen and androgen receptor (AR) may play important roles in several skin-related diseases, such as androgenetic alopecia and acne vulgaris.
|
22829074 |
2012 |
|
Androgenetic Alopecia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Publications addressing the association between AR gene polymorphisms and risk for AGA were selected from the PubMed, EMBASE and CBMdisc databases.
|
21981665 |
2012 |
|
Androgenetic Alopecia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The two major susceptibility loci for AGA are the androgen receptor (AR)/ectodysplasin A2 receptor (EDA2R) locus on the X-chromosome, and a locus on chromosome 20p11, for which no candidate gene has yet been identified.
|
22309448 |
2012 |
|
Androgenetic Alopecia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, in the coculture of AR-overexpressing human dermal papilla cells from AGA and normal human keratinocytes, R1881 suppresses keratinocyte growth through androgen-inducible TGF-β1, indicating that TGF-β1 is one of the key players in pathogenesis of AGA.
|
21167691 |
2011 |
|
Androgenetic Alopecia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therapeutic hotline. Genetic variations in the androgen receptor gene and finasteride response in women with androgenetic alopecia mediated by epigenetics.
|
21410621 |
2011 |
|
Androgenetic Alopecia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We previously reported greater therapeutic efficacy of finasteride in Japanese male androgenetic alopecia (MAGA) patients in cases where the CAG repeats of the androgen receptor (AR) gene were short.
|
21352305 |
2011 |
|
Androgenetic Alopecia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism of the androgen receptor gene was first identified in association with androgenetic alopecia.
|
20426708 |
2010 |
|
Androgenetic Alopecia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene.
|
21073542 |
2010 |
|
Androgenetic Alopecia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Keratin 5-human AR transgenic mice exposed to high levels of 5alpha-dihydrotestosterone showed delayed hair regeneration, mimicking the AGA scalp.
|
20233794 |
2010 |
|
Androgenetic Alopecia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In contrast with male AGA, no association was found between type II AGA in Egyptian women and the AR gene.
|
19538365 |
2009 |
|
Androgenetic Alopecia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in the human androgen receptor gene (AR) are associated with male pattern baldness (androgenetic alopecia, AGA) in Europeans.
|
19373488 |
2009 |
|
Androgenetic Alopecia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results suggest this form of genomic variation at the AR locus is unlikely to predispose to AGA.
|
19340294 |
2009 |
|
Androgenetic Alopecia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 x 10(-15)).
|
18849991 |
2008 |
|
Androgenetic Alopecia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Baldness and the androgen receptor: the AR polyglycine repeat polymorphism does not confer susceptibility to androgenetic alopecia.
|
17256155 |
2007 |