|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, selective depletion of this population in CD11b-diphtheria toxin receptor mice significantly delayed liver repair.
|
30814596 |
2019 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
To test the hypothesis that macrophages are essential for remodeling the cervix in preparation for birth, pregnant homozygous CD11b-dtr mice were injected with diphtheria toxin (DT) on days 14 and 16 postbreeding.
|
30629144 |
2019 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
In experiments 2 and 3, female transgenic mice (C57BL/6J background) expressing the human diphtheria toxin receptor under the control of the CD11b promoter had macrophage depletion by diphtheria toxin injection after induction of endometriosis.
|
30314882 |
2018 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
These alterations could be confirmed in an independent macrophage depletion model using CD11b-diphtheria toxin receptor mice.
|
27013602 |
2017 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Microglial depletion was performed by intracerebroventricular delivering diphtheria toxin to CD11b-diphtheria toxin receptor mice.
|
28698257 |
2017 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
We established hepatic metastases in transgenic CD11b-diphtheria toxin receptor mice by intrasplenic injection of MC38 colon and Lewis lung carcinoma cells before depleting myeloid cells with diphtheria toxin.
|
25854806 |
2015 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
To help resolve this, we used mice transgenic for the human diphtheria toxin receptor under the control of the CD11b promoter and treated them with diphtheria toxin, or liposomal clodronate, or both to deplete monocyte/mononuclear phagocytes prior to renal ischemia/reperfusion injury.
|
22673886 |
2012 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Targeted, conditional depletion of monocytes/macrophages was achieved by administration of diphtheria toxin (DT) to CD11b-DTR mice.
|
21343291 |
2011 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using the CD11b-diphtheria toxin receptor (DTR) mouse, in which expression of human DTR is under the control of the macrophage-specific promoter sequence CD11b, ovarian macrophages were specifically ablated in adult females by injections of diphtheria toxin (DT).
|
21393340 |
2011 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine whether infiltrating macrophages, a hallmark of this disease, are deleterious or beneficial in the injury process, we developed Lck-TSLP transgenic mice expressing the human diphtheria toxin receptor (DTR) under control of the monocyte/macrophage-restricted CD11b promoter (Lck-TSLP;CD11b-DTR).
|
21814168 |
2011 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conditional cellular depletion and reconstitution in CD11b promoter-driven diphtheria toxin receptor transgenic mice revealed that host macrophages played an essential role in the generation of the inflammatory response and were the source of the required IL-1alpha.
|
20220089 |
2010 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Monocyte/macrophage suppression in CD11b diphtheria toxin receptor transgenic mice differentially affects atherogenesis and established plaques.
|
17322176 |
2007 |
|
Diphtheria
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We developed a novel conditional Mphi ablation transgenic mouse (designated CD11bDTR) based upon CD11b promoter-mediated expression of the human diphtheria toxin (DT) receptor.
|
15699170 |
2005 |